Reynolds Mark A, Dawson Dolphus R, Novak Karen F, Ebersole Jeffrey L, Gunsolley John C, Branch-Mays Grishondra L, Holt Stanley C, Mattison Julie A, Ingram Donald K, Novak M John
Department of Periodontics, University of Maryland, Dental School, Baltimore, Maryland, USA.
Nutrition. 2009 Jan;25(1):88-97. doi: 10.1016/j.nut.2008.07.003. Epub 2008 Oct 16.
Dietary caloric restriction (CR) has been found to reduce systemic markers of inflammation and may attenuate the effects of chronic inflammatory conditions. The purpose of this study was to examine the effects of long-term CR on naturally occurring chronic inflammatory periodontal disease in a nonhuman primate model.
The effects of long-term CR on extent and severity of naturally occurring chronic periodontal disease, local inflammatory and immune responses, and periodontal microbiology, were evaluated in a cohort of 81 (35 female and 46 male; 13-40 y of age) rhesus monkeys (Macaca mulatta) with no previous exposure to routine oral hygiene. CR monkeys had been subjected to 30% CR for 13-17 y relative to control-fed (CON) animals starting at 3-5 y of age.
Same sex CR and CON monkeys exhibited similar levels of plaque, calculus, and bleeding on probing. Among CON animals, males showed significantly greater periodontal breakdown, as reflected by higher mean clinical attachment level and periodontal probing depth scores, than females. CR males exhibited significantly less periodontal pocketing, lower IgG antibody response, and lower IL-8 and ss-glucuronidase levels compared to CON males, whereas CR females showed a lower IgG antibody response but comparable clinical parameters and inflammatory marker levels relative to CON females. Long-term CR had no demonstrable effect on the periodontal microbiota.
Males demonstrated greater risk for naturally occurring periodontal disease than females. Long-term CR may differentially reduce the production of local inflammatory mediators and risk for inflammatory periodontal disease among males but not females.
已发现饮食热量限制（CR）可降低全身炎症标志物水平，并可能减轻慢性炎症性疾病的影响。本研究的目的是在非人类灵长类动物模型中检验长期热量限制对自然发生的慢性炎症性牙周病的影响。
在一组81只（35只雌性和46只雄性；年龄13 - 40岁）从未接受过常规口腔卫生护理的恒河猴（猕猴）中，评估长期热量限制对自然发生的慢性牙周病的范围和严重程度、局部炎症和免疫反应以及牙周微生物学的影响。与对照喂养（CON）的动物相比，热量限制组的猴子从3 - 5岁开始就接受了13 - 17年30%的热量限制。
同性别的热量限制组和对照喂养组猴子在菌斑、牙石和探诊出血水平上相似。在对照喂养组动物中，雄性的牙周破坏明显更严重，表现为平均临床附着水平和牙周探诊深度评分更高，高于雌性。与对照喂养组雄性相比，热量限制组雄性的牙周袋形成明显更少，IgG抗体反应更低，IL - 8和β - 葡萄糖醛酸酶水平更低，而热量限制组雌性的IgG抗体反应较低，但与对照喂养组雌性相比，临床参数和炎症标志物水平相当。长期热量限制对牙周微生物群没有明显影响。
雄性患自然发生的牙周病的风险高于雌性。长期热量限制可能会不同程度地降低雄性而非雌性局部炎症介质的产生以及炎症性牙周病的风险。
