Paladino J D, Hotchkiss J R, Rabb H
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Microvasc Res. 2009 Jan;77(1):8-12. doi: 10.1016/j.mvr.2008.09.001. Epub 2008 Sep 11.
An increasing body of evidence suggests that the deleterious effects of Acute Kidney Injury (AKI) on remote organ function could, at least in part, be due to loss of the normal balance of immune, inflammatory, and soluble mediator metabolism that attends injury of the tubular epithelium. Such dysregulation, acting at least in part on endothelium, leads to compromise of remote organ function. Kidney-lung interaction in the setting of AKI therefore constitutes not only a pressing clinical problem, but also an illuminating framework in which to consider possible mechanisms by which renal diseases exert such deleterious effects on patient outcomes, even when dialysis is provided.
越来越多的证据表明，急性肾损伤（AKI）对远隔器官功能的有害影响，至少部分可能是由于肾小管上皮损伤时免疫、炎症和可溶性介质代谢的正常平衡丧失所致。这种失调至少部分作用于内皮细胞，导致远隔器官功能受损。因此，AKI情况下的肾-肺相互作用不仅构成了一个紧迫的临床问题，也是一个有启发性的框架，可据此思考肾脏疾病对患者预后产生此类有害影响的可能机制，即使在进行透析的情况下也是如此。
