Myoui A, Aozasa K, Iuchi K, Mori T, Yamamoto S, Kuratsu S, Ohsawa M, Ono K, Matsumoto K
Department of Pathology, Osaka University Medical School, Japan.
Cancer. 1991 Oct 1;68(7):1550-4. doi: 10.1002/1097-0142(19911001)68:7<1550::aid-cncr2820680716>3.0.co;2-i.
Seventeen cases of soft tissue sarcoma (STS) developing in the pleural cavity were collected from Japanese hospitals, and their clinical and pathologic findings summarized. Eight of the 17 patients had a 15-year to 50-year (mean, 28.8) history of chronic pleural inflammatory disease (pleuritis, pyothorax, and pulmonary tuberculosis) before the onset of the pleural sarcoma. Histologically, malignant fibrous histiocytoma was the most common tumor type (11 cases), followed by angiosarcoma (four). The age at diagnosis of the sarcoma ranged from 15 to 74 years (mean, 58); the male-to-female ratio was 3.3:1. In the eight cases of sarcoma associated with chronic pleural inflammatory disease, male preponderance was more marked (7:1). The commonest presenting symptom was chest pain. A mass could be detected by chest roentgenograms in 13 patients and computed tomographic scans in 15 patients. No patient had distant metastases at first admission. Thirteen patients were treated by surgery, chemotherapy, and/or radiation therapy. Thirteen of the 17 patients died 1 to 87 months (mean, 14.2) after therapy for STS. The actuarial 1-year survival rate was 38.5%. These findings suggest that long-standing pleural inflammation might be an etiologic factor for development of pleural STS.
从日本医院收集了17例发生于胸腔的软组织肉瘤（STS）病例，并总结了其临床和病理特征。17例患者中有8例在胸腔肉瘤发病前有15年至50年（平均28.8年）的慢性胸膜炎性疾病（胸膜炎、脓胸和肺结核）病史。组织学上，恶性纤维组织细胞瘤是最常见的肿瘤类型（11例），其次是血管肉瘤（4例）。肉瘤诊断时的年龄为15岁至74岁（平均58岁）；男女比例为3.3:1。在8例与慢性胸膜炎性疾病相关的肉瘤病例中，男性优势更为明显（7:1）。最常见的症状是胸痛。13例患者胸部X线片可检测到肿块，15例患者计算机断层扫描可检测到肿块。首次入院时无患者有远处转移。13例患者接受了手术、化疗和/或放疗。17例患者中有13例在接受STS治疗后1至87个月（平均14.2个月）死亡。精算1年生存率为38.5%。这些发现表明，长期的胸膜炎可能是胸腔STS发生的一个病因。
