Vanin A F
Institute of Chemical Physics, Academy of Sciences of USSR, Moscow.
FEBS Lett. 1991 Sep 2;289(1):1-3. doi: 10.1016/0014-5793(91)80894-9.
A hypothesis is put forward on the nature of the endothelium-derived relaxing factor (EDRF) which is released from vascular endothelial cells by acetylcholine, bradykinin and other agonists. It is suggested that EDRF is a nitrosyl iron complex with low-molecular thiol ligands, most probably with cysteine. Its active principle is nitric oxide (NO). This free radical is stabilized by inclusion into the iron complex, which promotes NO transfer within the cell and between cells. Subsequent release of NO from these complexes results from thiol group oxidation.
针对内皮源性舒张因子（EDRF）的性质提出了一种假说，该因子由乙酰胆碱、缓激肽及其他激动剂从血管内皮细胞释放。有人认为EDRF是一种与低分子硫醇配体形成的亚硝酰铁络合物，很可能是与半胱氨酸形成的络合物。其活性成分是一氧化氮（NO）。这种自由基通过被纳入铁络合物而得以稳定，这促进了NO在细胞内及细胞间的传递。这些络合物随后通过硫醇基团氧化而释放出NO。
