Serri Riccarda, Iorizzo Matilde
Department of Dermatology, University of Milan, Milan, Italy.
Clin Dermatol. 2008 Nov-Dec;26(6):633-5. doi: 10.1016/j.clindermatol.2007.09.016.
Evidence from a randomized clinical trial showed that, in spite of the many surgical procedures effective in ameliorating the clinical appearance of photoaged skin, the only medical therapy with proven benefits in photoaged skin are topical retinoids, in particular tretinoin, isotretinoin, and tazarotene. The application of retinoids might not only clinically and biochemically repair photoaged skin, but their use might also prevent photoaging. Furthermore, new evidence suggests a beneficial role of topical retinoids in the treatment of intrinsically aged skin.
一项随机临床试验的证据表明，尽管有许多外科手术可有效改善光老化皮肤的临床表现，但在光老化皮肤中已证实有好处的唯一药物治疗是局部用维甲酸，特别是维甲酸、异维甲酸和他扎罗汀。维甲酸的应用不仅可以在临床和生化方面修复光老化皮肤，而且其使用还可能预防光老化。此外，新证据表明局部用维甲酸在治疗自然老化皮肤方面具有有益作用。
