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疑似过敏性接触性皮炎儿童的斑贴试验:一项前瞻性研究及文献综述

Patch tests in children with suspected allergic contact dermatitis: a prospective study and review of the literature.

作者信息

de Waard-van der Spek Flora B, Oranje Arnold P

机构信息

Paediatric Dermatology Unit, Department of Dermatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

出版信息

Dermatology. 2009;218(2):119-25. doi: 10.1159/000165629. Epub 2008 Oct 22.

Abstract

AIMS

The results of patch testing in children visiting our out-patient clinic with suspected allergic contact dermatitis (ACD) were prospectively investigated and compared with those reported in the literature. A review of the literature on patch testing and ACD in children is provided.

METHODS

Children were patch tested using the TRUE test, supplemented with tixocortol-17-pivalate, budesonide and 3 commonly used emollients. Supplementary patch tests were undertaken on indication.

RESULTS

Seventy-nine children (31 boys and 48 girls) were patch tested. Of the patients tested, 40 (51%) had 1 or more positive allergic patch test reactions. Twenty-two (55%) of these 40 children suffered from atopic dermatitis, 9 (23%) from hand or foot dermatitis, and 9 (23%) from other skin ailments. Nickel was the most common contact allergen, but many other common and less common allergens were noted to give positive patch tests in patients.

CONCLUSION

Sensitization to contact allergens may begin in infancy and continue to be more common in toddlers and young children. In recalcitrant atopic dermatitis, especially at the age of 5 years and over, patch tests are indicated. Good information on preventing the development of ACD in children is useful for caregivers.

摘要

目的

对到我院门诊就诊的疑似过敏性接触性皮炎(ACD)儿童的斑贴试验结果进行前瞻性研究,并与文献报道结果进行比较。同时提供有关儿童斑贴试验和ACD的文献综述。

方法

采用TRUE试验对儿童进行斑贴试验,并补充17-特戊酸替可的松、布地奈德和3种常用润肤剂。根据指征进行补充斑贴试验。

结果

对79名儿童(31名男孩和48名女孩)进行了斑贴试验。在接受测试的患者中,40名(51%)有1次或更多次阳性过敏性斑贴试验反应。这40名儿童中,22名(55%)患有特应性皮炎,9名(23%)患有手足皮炎,9名(23%)患有其他皮肤疾病。镍是最常见的接触性过敏原,但也注意到许多其他常见和不太常见的过敏原在患者中斑贴试验呈阳性。

结论

对接触性过敏原的致敏可能始于婴儿期,在幼儿和年幼儿童中更为常见。在顽固性特应性皮炎中,尤其是5岁及以上儿童,建议进行斑贴试验。为护理人员提供有关预防儿童发生ACD的良好信息很有用。

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