Valdés Aymé Fernández-Calienes, Martínez Judith Mendiola, Lizama Ramón Scull, Vermeersch Marieke, Cos Paul, Maes Louis
Departamento de Parasitología, Instituto de Medicina Tropical Pedro Kourí, Marianao, La Habana, Cuba.
Mem Inst Oswaldo Cruz. 2008 Sep;103(6):615-8. doi: 10.1590/s0074-02762008000600019.
In the present study, an extensive in vitro antimicrobial profiling was performed for three medicinal plants grown in Cuba, namely Simarouba glauca, Melaleuca leucadendron and Artemisia absinthium. Ethanol extracts were tested for their antiprotozoal potential against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum and Plasmodium falciparum. Antifungal activities were evaluated against Microsporum canis and Candida albicans whereas Escherichia coli and Staphylococcus aureus were used as test organisms for antibacterial activity. Cytotoxicity was assessed against human MRC-5 cells. Only M. leucadendron extract showed selective activity against microorganisms tested. Although S. glauca exhibited strong activity against all protozoa, it must be considered non-specific. The value of integrated evaluation of extracts with particular reference to selectivity is discussed.
在本研究中，对古巴生长的三种药用植物，即苦木、白千层和洋艾进行了广泛的体外抗菌谱分析。测试了乙醇提取物对布氏锥虫、克氏锥虫、婴儿利什曼原虫和恶性疟原虫的抗原虫潜力。评估了其对犬小孢子菌和白色念珠菌的抗真菌活性，而大肠杆菌和金黄色葡萄球菌用作抗菌活性测试生物。评估了对人MRC-5细胞的细胞毒性。只有白千层提取物对测试的微生物表现出选择性活性。尽管苦木对所有原生动物都表现出强活性，但必须认为是非特异性的。讨论了特别参考选择性对提取物进行综合评价的价值。
