Rona Roberto J, Jones Margaret, Iversen Amy, Hull Lisa, Greenberg Neil, Fear Nicola T, Hotopf Matthew, Wessely Simon
King's Centre for Military Health Research, Department of Psychological Medicine, Institute of Psychiatry, King's College London, Weston Education Centre, Cutcombe Road, London SE1 9RJ, UK.
J Psychiatr Res. 2009 Mar;43(6):649-55. doi: 10.1016/j.jpsychires.2008.09.006. Epub 2008 Oct 23.
The aims of this study were to assess: (1) the relationship between PTSD and impairment, (2) whether there is a threshold in the association of PTSD score and impairment, and (3) whether any of the PTSD criteria are more strongly associated with impairment. We studied 10,069 service personnel from a representative sample of the British Armed Forces to assess the effects of the Iraq war. Participants completed the PTSD checklist (PCL), the general health questionnaire-12 (GHQ-12), the alcohol use disorder identification test (AUDIT) and five questions to assess impairment. 78% of those with a PCL-score of 50 or more endorsed at least one impairment item in comparison to 27% of those with a score below 50. The odds ratio (OR) of impairment in the PCL group with a score of 50 or more was 16.7 (95% CI 12.9-21.6). There was an increasing risk of impairment with an increasing category of PCL-score without a noticeable threshold. For each PTSD subscale: intrusiveness, avoidance/numbing and hyper-arousal, divided into four score categories, there was an increased association with impairment, but the association of avoidance/numbing with impairment was the greatest and independent of the other two criteria (OR 7.2 (95% CI 4.8-10.9). Having a good relationship with a partner had minimal effect on the level of association between PTSD and impairment. Functional impairment is a serious problem for those with PTSD. The impairment is not confined to those with the highest PCL-score. Avoidance/numbing is the criterion which makes the greatest independent contribution to impairment.
(1)创伤后应激障碍(PTSD)与功能损害之间的关系;(2)PTSD评分与功能损害之间的关联是否存在阈值;(3)PTSD的任何一项标准是否与功能损害的关联更强。我们对来自英国武装部队代表性样本的10,069名军人进行了研究,以评估伊拉克战争的影响。参与者完成了PTSD检查表(PCL)、一般健康问卷-12(GHQ-12)、酒精使用障碍识别测试(AUDIT)以及五个评估功能损害的问题。PCL评分50分及以上者中有78%认可至少一项功能损害项目,而评分低于50分者中这一比例为27%。PCL评分50分及以上组功能损害的优势比(OR)为16.7(95%置信区间12.9 - 21.6)。随着PCL评分类别增加,功能损害风险增加,且无明显阈值。对于PTSD的每个子量表:侵入性、回避/麻木和过度警觉,分为四个评分类别,与功能损害的关联均增加,但回避/麻木与功能损害的关联最大,且独立于其他两项标准(OR 7.2(95%置信区间4.8 - 10.9))。与伴侣关系良好对PTSD与功能损害之间的关联程度影响最小。功能损害对PTSD患者来说是一个严重问题。功能损害并不局限于PCL评分最高的患者。回避/麻木是对功能损害做出最大独立贡献的标准。