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[乙替米唑对家兔下丘脑核中超慢电振荡及去甲肾上腺素浓度的影响]

[Effect of etimizol on super-slow electrical oscillations and the concentration of noradrenaline in nuclei of the rabbit hypothalamus].

作者信息

Lapina I A, Moreva E V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1976 Nov-Dec;26(6):1296-1300.

PMID:189524
Abstract

Following intramuscular administration of a 2.5 mg/kg dose of ethymisol to curarized rabbits with implanted gold electrodes in the anterior group of hypothalamic nuclei, a correlation was revelaed between the amplitude of superslow electrical oscillations of 0 to 1 c/s and the noradrenaline content in the brain tissue. After ethymisol administration, the positive wave of the slow oscillation disappeared, while the adrenaline content in the hypothalamic area decreased from 0.93 mkg/g to 0.16 mkg/g of the tissue. By means of phentolamine and propranolol adrenoblockators the participation of alpha-and beta-receptors of the hypothalamus in the ethymisol effect has been proved.

摘要

给植入了位于下丘脑前组核的金电极的箭毒化家兔肌肉注射2.5毫克/千克剂量的乙胺碘呋酮后,发现0至1次/秒的超慢电振荡幅度与脑组织中去甲肾上腺素含量之间存在相关性。注射乙胺碘呋酮后,慢振荡的正波消失,而下丘脑区域的肾上腺素含量从每克组织0.93微克降至0.16微克。通过酚妥拉明和普萘洛尔这两种肾上腺素能阻滞剂,已证明下丘脑的α和β受体参与了乙胺碘呋酮的作用。

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