Lapina I A, Iaichnikov I K, Shabanov P D, Filipovich A I
Farmakol Toksikol. 1984 Jul-Aug;47(4):18-21.
It has been demonstrated in experiments on rabbits with golden electrodes and thermocouples implanted to the brain that ethimizol (1.5 mg/kg) and 1-ethyl-4,5-di-(N.-methylcarbamoyl)-pyrazole (IEM-476, 3 mg/kg) altered the amplitude and frequency of ultraslow wave potentials and decreased the temperature of the hypothalamus, dorsal hippocamp and neocortex. Allylnorantifein (1-allyl-4,5-di-(N-methylcarbamoyl)-imidazole, 3 mg/kg) and 1-allyl-4,5-di-(N-methylcarbamoyl)-pyrazole (IEM-474, 3 mg/kg) altered the amplitude and frequency of ultraslow wave potentials of middle brain reticular formation nuclei, medial thalamic nuclei and of the neocortex, the structures of the nonspecific ascending system of the brain, and did not influence the temperature of the brain. The effects of IEM-476 and IEM-474 on the indicators under study were less powerful than those of ethimizol and allylnortifein.
在对植入金电极和热电偶的兔子进行的实验中已证明，乙嘧唑（1.5毫克/千克）和1-乙基-4,5-二（N-甲基氨基甲酰基）吡唑（IEM-476，3毫克/千克）改变了超慢波电位的幅度和频率，并降低了下丘脑、背侧海马和新皮层的温度。烯丙基去甲安替芬（1-烯丙基-4,5-二（N-甲基氨基甲酰基）咪唑，3毫克/千克）和1-烯丙基-4,5-二（N-甲基氨基甲酰基）吡唑（IEM-474，3毫克/千克）改变了中脑网状结构核、内侧丘脑核和新皮层（大脑非特异性上行系统的结构）的超慢波电位的幅度和频率，并且不影响大脑温度。IEM-476和IEM-474对所研究指标的作用比乙嘧唑和烯丙基去甲安替芬的作用弱。
