McLean David, Mannetje Andrea 't, Dryson Evan, Walls Chris, McKenzie Fiona, Maule Milena, Cheng Soo, Cunningham Chris, Kromhout Hans, Boffetta Paolo, Blair Aaron, Pearce Neil
Centre for Public Health Research, Massey University, Wellington, New Zealand.
Int J Epidemiol. 2009 Apr;38(2):594-606. doi: 10.1093/ije/dyn220. Epub 2008 Oct 25.
To examine the association between occupation and leukaemia.
We interviewed 225 cases (aged 20-75 years) notified to the New Zealand Cancer Registry during 2003-04, and 471 controls randomly selected from the Electoral Roll collecting demographic details, information on potential confounders and a comprehensive employment history. Associations between occupation and leukaemia were analysed using logistic regression adjusted for gender, age, ethnicity and smoking.
Elevated odds ratios (ORs) were observed in agricultural sectors including horticulture/fruit growing (OR: 2.62, 95% confidence interval (CI): 1.51, 4.55), plant nurseries (OR: 7.51, 95% CI: 1.85, 30.38) and vegetable growing (OR: 3.14, 95% CI: 1.18, 8.40); and appeared greater in women (ORs: 4.71, 7.75 and 7.98, respectively). Elevated ORs were also observed in market farmers/crop growers (OR: 1.84, 95% CI: 1.12, 3.02), field crop/vegetable growers (OR: 3.98, 95% CI: 1.46, 10.85), market gardeners (OR: 5.50, 95% CI: 1.59, 19.02), and nursery growers/workers (OR: 4.23, 95% CI: 1.34, 13.35); also greater in women (ORs: 3.48, 7.62, 15.74 and 11.70, respectively). These elevated ORs were predominantly for chronic lymphocytic leukaemia (CLL). Several associations persisted after semi-Bayes adjustment. Elevated ORs were observed in rubber/plastics products machine operators (OR: 3.76, 95% CI: 1.08, 13.08), predominantly in plastic product manufacturing. CLL was also elevated in tailors and dressmakers (OR: 7.01, 95% CI: 1.78, 27.68), cleaners (OR: 2.04, 95% CI: 1.00, 4.14) and builder's labourers (OR: 4.03, 95% CI: 1.30, 12.53).
These findings suggest increased leukaemia risks associated with certain agricultural, manufacturing, construction and service occupations in New Zealand.
研究职业与白血病之间的关联。
我们对2003年至2004年期间向新西兰癌症登记处报告的225例病例（年龄在20 - 75岁之间）进行了访谈，并从选民名册中随机选取了471名对照，收集人口统计学细节、潜在混杂因素信息以及全面的就业史。使用对性别、年龄、种族和吸烟进行调整的逻辑回归分析职业与白血病之间的关联。
在包括园艺/水果种植（比值比（OR）：2.62，95%置信区间（CI）：1.51，4.55）、植物苗圃（OR：7.51，95% CI：1.85，30.38）和蔬菜种植（OR：3.14，95% CI：1.18，8.40）在内的农业部门中观察到比值比升高；且在女性中更为明显（OR分别为4.71、7.75和7.98）。在市场农民/作物种植者（OR：1.84，95% CI：1.12，3.02）、大田作物/蔬菜种植者（OR：3.98，95% CI：1.46，10.85）、商品菜农（OR：5.50，95% CI：1.59，19.02）以及苗圃种植者/工人（OR：4.23，95% CI：1.34，13.35）中也观察到比值比升高；同样在女性中更为明显（OR分别为3.48、7.62、15.74和11.70）。这些升高的比值比主要针对慢性淋巴细胞白血病（CLL）。经过半贝叶斯调整后，几种关联仍然存在。在橡胶/塑料制品机器操作员中观察到比值比升高（OR：3.76，95% CI：1.08，13.08），主要集中在塑料制品制造行业。裁缝和女裁缝（OR：7.01，95% CI：1.78，27.68）、清洁工（OR：2.04，95% CI：1.00，4.14）以及建筑工人（OR：4.03，95% CI：1.30，12.53）中的CLL发病率也有所升高。
这些发现表明，在新西兰，某些农业、制造业、建筑业和服务业职业与白血病风险增加有关。
