Department of Community Medicine, Department of Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Evid Based Complement Alternat Med. 2009 Dec;6(4):495-501. doi: 10.1093/ecam/nem141. Epub 2007 Oct 25.
Nephrolithiasis in the communities of Northeast Thailand frequently presents with multiple chronic health complaints, i.e. myofascial pain, back pain, dyspepsia, arthralgia, headache, fatigue, frank paresthesia, dysuria and any of these aggravated by purine-rich food (PRF). We assessed the efficacy of Orthosiphon in treating subjects with at least two active symptoms and negative for urine white blood cells. Subjects were randomly allocated to two groups. Crude extract of Orthosiphon given in a capsule (equivalent to 1.6-1.8 g of dried leaves of Orthosiphon) two times a day to Group 1 (n = 36) and a placebo to Group 2 (n = 40) for 14 days. The medication for each subject was packed and its code kept secret until the data analysis. Both groups were asked not to consume any of 25 purine-rich foods (PRFs) during treatment. The primary measure was the reduced sum of active severity symptoms as recorded using the visual analog scale before and after therapy (i.e. on day 7 and 14). The data on 76 subjects were processed. The mean of the total scores (95% CI) of the symptoms in each group were decreased significantly (P < 0.001); 185.6 (153.3, 218.0) to 94.7 (58.2, 131.2) in the Orthosiphon group and 196.1 (164.4, 227.8) to 89.6 (62.8, 116.5) in the placebo group. When comparing between groups, no statistically significant difference was found. The mean consumption in PRFs was significantly decreased (P < 0.001) in both groups; however, Orthosiphon did not have additional benefit over placebo at 7 and 14 days of treatment during which they reduced these foods.
泰国东北部社区的肾结石患者常伴有多种慢性健康问题，如肌筋膜疼痛、背痛、消化不良、关节痛、头痛、疲劳、感觉异常、排尿困难以及任何因富含嘌呤的食物（PRF）而加重的症状。我们评估了三叶苦对至少有两种活跃症状且尿液白细胞阴性的患者的治疗效果。将患者随机分为两组。一组给予三叶苦粗提取物胶囊（相当于 1.6-1.8 克三叶苦干叶），每日两次（n=36）；另一组给予安慰剂（n=40），疗程为 14 天。每位患者的药物均包装并保密，直到数据分析。两组患者在治疗期间均被要求不食用 25 种富含嘌呤的食物（PRF）。主要观察指标是治疗前后（即第 7 天和第 14 天）使用视觉模拟量表记录的活跃严重症状总和的减少。对 76 例患者的数据进行了处理。每组症状的总分平均值（95%CI）均显著降低（P<0.001）：三叶苦组从 185.6（153.3，218.0）降至 94.7（58.2，131.2），安慰剂组从 196.1（164.4，227.8）降至 89.6（62.8，116.5）。组间比较差异无统计学意义。两组 PRF 的平均摄入量均显著降低（P<0.001）；然而，在治疗的第 7 和第 14 天，与安慰剂相比，三叶苦并没有额外的获益，且患者在这两个时间点都减少了这些食物的摄入。
