Chinese Herbal Medicine Program, Division of Research and Development, Development Center for Biotechnology, Taipei, Taiwan, ROC.
Evid Based Complement Alternat Med. 2010 Mar;7(1):115-20. doi: 10.1093/ecam/nem168. Epub 2007 Nov 23.
Plectranthus amboinicus (P. amboinicus) is a folk herb that is used to treat inflammatory diseases or swelling symptoms in Taiwan. We investigated therapeutic efficacy of P. amboinicus in treating Rheumatoid Arthritis (RA) using collagen-induced arthritis animal model. Arthritis was induced in Lewis rats by immunization with bovine type II collagen. Serum anti-collagen IgG, IgM and C-reactive protein (CRP) were analyzed. To understand the inflammation condition of treated animals, production of TNF-α, IL-6 and IL-1β from peritoneal exudates cells (PEC) were also analyzed. P. amboinicus significantly inhibited the footpad swelling and arthritic symptoms in collagen-induced arthritic rats, while the serum anti-collagen IgM and CRP levels were consistently decreased. The production of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β were also decreased in the high dosage of P. amboinicus group. Here, we demonstrate the potential anti-arthritic effect of P. amboinicus for treating RA, which might confer its anti-rheumatic activity. This differs the pharmacological action mode of indomethacin.
岗梅（P. amboinicus）是一种民间草药，用于治疗台湾的炎症性疾病或肿胀症状。我们使用牛 II 型胶原免疫诱导的胶原诱导性关节炎动物模型来研究岗梅治疗类风湿关节炎（RA）的疗效。关节炎通过用牛 II 型胶原免疫Lewis 大鼠而诱发。分析血清抗胶原 IgG、IgM 和 C 反应蛋白（CRP）。为了了解治疗动物的炎症情况，还分析了腹腔渗出细胞（PEC）中 TNF-α、IL-6 和 IL-1β的产生。岗梅能显著抑制胶原诱导性关节炎大鼠的足垫肿胀和关节炎症状，同时血清抗胶原 IgM 和 CRP 水平持续下降。高剂量岗梅组中促炎细胞因子 TNF-α、IL-6 和 IL-1β的产生也减少。在这里，我们证明了岗梅治疗 RA 的潜在抗关节炎作用，这可能与其抗风湿活性有关。这与消炎痛的药理作用模式不同。
