Carman George M, Han Gil-Soo
Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA.
J Lipid Res. 2009 Apr;50 Suppl(Suppl):S69-73. doi: 10.1194/jlr.R800043-JLR200. Epub 2008 Oct 27.
Phospholipid synthesis in the yeast Saccharomyces cerevisiae is a complex process that involves regulation by both genetic and biochemical mechanisms. The activity levels of phospholipid synthesis enzymes are controlled by gene expression (e.g., transcription) and by factors (lipids, water-soluble phospholipid precursors and products, and covalent modification of phosphorylation) that modulate catalysis. Phosphatidic acid, whose levels are controlled by the biochemical regulation of key phospholipid synthesis enzymes, plays a central role in the regulation of phospholipid synthesis gene expression.
酿酒酵母中的磷脂合成是一个复杂的过程，涉及遗传和生化机制的调控。磷脂合成酶的活性水平受基因表达（如转录）以及调节催化作用的因素（脂质、水溶性磷脂前体和产物，以及磷酸化的共价修饰）控制。磷脂酸的水平由关键磷脂合成酶的生化调控控制，在磷脂合成基因表达的调控中起核心作用。
