Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic.
Molecules. 2018 Mar 15;23(3):660. doi: 10.3390/molecules23030660.
Hop ( L.), as a key ingredient for beer brewing, is also a source of many biologically active molecules. A notable compound, 8-prenylnaringenin (8-PN), structurally belonging to the group of prenylated flavonoids, was shown to be a potent phytoestrogen, and thus, became the topic of active research. Here, we overview the pharmacological properties of 8-PN and its therapeutic opportunities. Due to its estrogenic effects, administration of 8-PN represents a novel therapeutic approach to the treatment of menopausal and post-menopausal symptoms that occur as a consequence of a progressive decline in hormone levels in women. Application of 8-PN in the treatment of menopause has been clinically examined with promising results. Other activities that have already been assessed include the potential to prevent bone-resorption or inhibition of tumor growth. On the other hand, the use of phytoestrogens is frequently questioned regarding possible adverse effects associated with long-term consumption. In conclusion, we emphasize the implications of using 8-PN in future treatments of menopausal and post-menopausal symptoms, including the need for precise evidence and further investigations to define the safety risks related to its therapeutic use.
啤酒酿造的关键成分之一啤酒花（Hop），也是许多具有生物活性分子的来源。一种引人注目的化合物，8- 香叶基柚皮素（8-PN），在结构上属于类异戊烯基黄酮类，被证明是一种有效的植物雌激素，因此成为了活跃研究的主题。在这里，我们概述了 8-PN 的药理学特性及其治疗机会。由于其雌激素作用，8-PN 的给药代表了一种治疗绝经和绝经后症状的新的治疗方法，这些症状是女性激素水平逐渐下降的结果。8-PN 在治疗绝经方面的应用已经在临床上进行了检查，结果令人鼓舞。其他已经评估的活动包括预防骨质流失或抑制肿瘤生长的潜力。另一方面，植物雌激素的使用经常因其长期消费可能带来的不良影响而受到质疑。总之，我们强调了在未来治疗绝经和绝经后症状中使用 8-PN 的意义，包括需要精确的证据和进一步的研究来确定与治疗用途相关的安全风险。
