8-异戊烯基柚皮素的两种主要代谢产物在体外具有雌激素活性。

Two major metabolites of 8-prenylnaringenin are estrogenic in vitro.

作者信息

Zierau Oliver, Hauswald Stefanie, Schwab Pia, Metz Peter, Vollmer Günter

机构信息

Institute of Zoology, Dresden University of Technology, D-01062 Dresden, Germany.

出版信息

J Steroid Biochem Mol Biol. 2004 Sep;92(1-2):107-10. doi: 10.1016/j.jsbmb.2004.06.001.

DOI:10.1016/j.jsbmb.2004.06.001

PMID:15544936

Abstract

8-prenylnaringenin (8-PN) and preparations containing 8-prenylnaringenin have been suggested for use in medicinal and cosmetic applications like hormone replacement or bust enhancement. However, the safety of application is still under considerable debate. Recently it has been shown that human liver microsomes are converting 8-prenylnaringenin to 12 metabolites, with (E)-8-(4''-hydroxyisopentenyl)naringenin (8-PN-OH) and (E)-8-(4''-oxoisopentenyl)naringenin (8-PN=O) being among the most abundant. Applying two independent in vitro test systems we demonstrate that these two metabolites of 8-prenylnaringenin are estrogenic in vitro. These results represent an important piece of information towards the discussion of safety of use of preparations containing 8-prenylnaringenin.

摘要

8-异戊烯基柚皮素（8-PN）以及含有8-异戊烯基柚皮素的制剂已被建议用于激素替代或丰胸等医学和美容应用中。然而，其应用安全性仍存在很大争议。最近有研究表明，人肝微粒体可将8-异戊烯基柚皮素转化为12种代谢产物，其中（E）-8-（4''-羟基异戊烯基）柚皮素（8-PN-OH）和（E）-8-（4''-氧代异戊烯基）柚皮素（8-PN=O）是含量最丰富的代谢产物。通过应用两个独立的体外测试系统，我们证明了这两种8-异戊烯基柚皮素的代谢产物在体外具有雌激素活性。这些结果为讨论含8-异戊烯基柚皮素制剂的使用安全性提供了重要信息。