Gerrits G P, Monnens L A, De Abreu R A, Schröder C H, Trijbels J M, Gabreëls F J
Department of Pediatrics, University of Nijmegen, The Netherlands.
Nephron. 1991;58(3):310-4. doi: 10.1159/000186442.
Chronic renal failure during childhood may be associated with delayed cognitive development. From 10 children with chronic renal failure, aged 2-59 months, plasma and cerebrospinal fluid (CSF) purines and pyrimidines have been determined. A marked increase of pseudouridine and cytidine was demonstrated in CSF of 10 and 8 children, respectively. The plasma concentration of pseudouridine was increased in a varying degree to a maximal value of more than 10 times the upper limit of normal. The plasma concentration of cytidine showed only moderately elevated values. In 3 children the study of CSF and plasma was repeated 6 weeks after the start of continuous ambulatory peritoneal dialysis. The abnormal concentrations of pseudouridine and cytidine were still present in CSF and plasma. Further studies are necessary to elucidate the cause of this unknown biochemical aberration of the central nervous system.
儿童期慢性肾衰竭可能与认知发育迟缓有关。对10名年龄在2至59个月的慢性肾衰竭患儿测定了血浆和脑脊液中的嘌呤和嘧啶。分别在10名和8名患儿的脑脊液中发现假尿苷和胞苷显著增加。假尿苷的血浆浓度不同程度升高，最高值超过正常上限的10倍。胞苷的血浆浓度仅中度升高。3名患儿在开始持续非卧床腹膜透析6周后重复进行脑脊液和血浆研究。脑脊液和血浆中假尿苷和胞苷的异常浓度仍然存在。需要进一步研究以阐明这种中枢神经系统未知生化异常的原因。
