[海洋红树林真菌拟青霉属菌株1-7次生代谢产物对人肝癌细胞系HepG2的细胞毒性]
[Cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. tree 1-7 on human hepatoma cell line HepG2].
作者信息
Cai Xiao-Ling, Gao Jun-Ping, Li Qing, Wen Lu, She Zhi-Gang, Lin Yong-Cheng
机构信息
School of Chemical and Chemical Engineering,Sun Yat-sen University, Guangzhou 510275, China.
出版信息
Zhong Yao Cai. 2008 Jun;31(6):864-5.
OBJECTIVE
To study the cytotoxicity of the secondary metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1-7 on human hepatoma cell line HepG2 cultured in vitro.
METHODS
Three groups were divided: compounds group, 5-Fu group and control group. The cytotoxicity was measured by MTT method when HepG2 cells were treated by different concentration of the secondary metabolites of Paecilomyces sp. Tree 1-7.
RESULTS
Secalonic acid A, tenellic acid A and alternin inhibited the growth of human hepatoma cell line HepG2, the IC50 separately were 2.0, 62.1 and 7.0 microg/ml.
CONCLUSION
Secalonic acid A and alternin have strong cytotoxicity on HepG2 cultured in vitro.
目的
研究海洋红树林真菌拟青霉属Tree 1-7次生代谢产物对体外培养的人肝癌细胞系HepG2的细胞毒性。
方法
分为三组：化合物组、5-氟尿嘧啶组和对照组。用不同浓度的拟青霉属Tree 1-7次生代谢产物处理HepG2细胞，采用MTT法测定细胞毒性。
结果
黄绿青霉素A、细交链孢菌酮酸A和交替菌素抑制人肝癌细胞系HepG2的生长，IC50分别为2.0、62. 和7.0微克/毫升。
结论
黄绿青霉素A和交替菌素对体外培养的HepG2具有较强的细胞毒性。
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