Randelli Pietro, Margheritini Fabrizio, Cabitza Paolo, Dogliotti Giada, Corsi Massimiliano M
Dipartimento di Scienze Medico-Chirurgiche, Università degli Studi di Milano, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese 20097, Milan, Italy.
Knee Surg Sports Traumatol Arthrosc. 2009 Jan;17(1):98-101. doi: 10.1007/s00167-008-0653-4. Epub 2008 Oct 31.
It has recently been postulated that a variety of growth factors may be released from cancellous bone after an acromioplasty. The aim of this study was to demonstrate the presence of growth factors in the subacromial space after acromioplasty. Between October 2006 and March 2007, 23 patients underwent arthroscopic acromioplasty. A sample of at least 3 ml of fluid from the shoulder was obtained 15 min after the end of the procedure. At the same time another sample of 3 ml of the patient's venous blood was obtained as a control. The concentrations of growth factors in the fluids collected were determined using enzyme-linked immunosorbent assay (ELISA). The growth factors assayed were platelet-derived growth factor-AB (PDGF-AB), basic fibroblast growth factor basic (bFGF) and transforming growth factor beta 1 (TGF-beta1). The concentrations of TGF-beta1 (p = 0.0001), PDGF-AB (p = 0.02), and bFGF (p < 0.0001) were significantly higher in the fluid from the subacromial space than in the blood sample. There are high concentrations of several growth factors in the subacromial space after acromioplasty.
最近有人提出，肩峰成形术后松质骨可能会释放多种生长因子。本研究的目的是证实肩峰成形术后肩峰下间隙中生长因子的存在。2006年10月至2007年3月期间，23例患者接受了关节镜下肩峰成形术。手术结束15分钟后，从肩部获取至少3毫升的液体样本。同时，采集3毫升患者静脉血样本作为对照。使用酶联免疫吸附测定法（ELISA）测定所采集液体中生长因子的浓度。所检测的生长因子为血小板衍生生长因子-AB（PDGF-AB）、碱性成纤维细胞生长因子（bFGF）和转化生长因子β1（TGF-β1）。肩峰下间隙液体中TGF-β1（p = 0.0001）、PDGF-AB（p = 0.02）和bFGF（p < 0.0001）的浓度显著高于血样。肩峰成形术后肩峰下间隙中存在多种高浓度的生长因子。
