Andretic Rozi, Franken Paul, Tafti Mehdi
The Neuroscience Institute, San Diego, California 92121, USA.
Annu Rev Genet. 2008;42:361-88. doi: 10.1146/annurev.genet.42.110807.091541.
Molecular and genetic approaches in several species have provided new insights into the mechanisms of rest-activity and sleep-wake regulation. Many of these discoveries are believed to support hypotheses about sleep functions, which nevertheless remain elusive. In this review we discuss the specific contribution of both mammalian and invertebrate models to our understanding of the molecular basis of sleep.
对多个物种的分子和遗传学研究方法为静息-活动及睡眠-觉醒调节机制提供了新的见解。许多这些发现被认为支持了关于睡眠功能的假说，然而这些假说仍然难以捉摸。在这篇综述中，我们讨论了哺乳动物和无脊椎动物模型对于我们理解睡眠分子基础的具体贡献。
