Pettegrew J W, Keshavan M S, Panchalingam K, Strychor S, Kaplan D B, Tretta M G, Allen M
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pa 15213.
Arch Gen Psychiatry. 1991 Jun;48(6):563-8. doi: 10.1001/archpsyc.1991.01810300075011.
In this pilot study, membrane phospholipid and high-energy phosphate metabolism were studied in the dorsal prefrontal cortex of 11 drug-naive, first-episode schizophrenic patients and compared with those of 10 healthy control volunteers comparable in age, education, and parental education. The schizophrenic patients had significantly reduced levels of phosphomonoesters and inorganic orthophosphate and significantly increased levels of phosphodiesters and adenosine triphosphate compared with the controls. The levels of phosphocreatine and adenosine diphosphate did not differ in the two subject groups. The adenosine triphosphate and inorganic orthophosphate findings suggest functional hypoactivity of the dorsal prefrontal cortex. The phosphomonoester and phosphodiester findings are compatible with either premature aging or an exaggeration of normal programmed regressive events occurring in the neural systems sampled.
在这项初步研究中，对11名未服用过药物的首发精神分裂症患者背侧前额叶皮质的膜磷脂和高能磷酸代谢进行了研究，并与10名年龄、教育程度和父母教育程度相当的健康对照志愿者进行了比较。与对照组相比，精神分裂症患者的磷酸单酯和无机正磷酸盐水平显著降低，磷酸二酯和三磷酸腺苷水平显著升高。两组受试者的磷酸肌酸和二磷酸腺苷水平没有差异。三磷酸腺苷和无机正磷酸盐的研究结果表明背侧前额叶皮质功能减退。磷酸单酯和磷酸二酯的研究结果与过早衰老或所采样的神经系统中正常程序性退行性事件的过度发生相符。
