Pettegrew J W, Keshavan M S, Minshew N J
University of Pittsburgh/WPIC, Graduate School of Public Health, PA 15213.
Schizophr Bull. 1993;19(1):35-53. doi: 10.1093/schbul/19.1.35.
A number of studies have demonstrated alterations in the structure and function of the frontolimbic system in some schizophrenic patients. Recent in vivo phosphorus-31 nuclear magnetic resonance studies of the dorsal prefrontal cortex in neuroleptic-naive, first-episode schizophrenic patients and matched controls have shown evidence of alterations in membrane phospholipid and energy metabolism. The membrane alterations observed in the schizophrenic patients are compatible with either premature aging or altered timing and exaggeration of regressive events occurring during normal brain development. These molecular changes may precede onset of clinical symptoms and brain structural changes in schizophrenia and suggest fresh approaches to the pathogenesis and treatment of this illness.
多项研究表明，一些精神分裂症患者的额颞叶系统结构和功能存在改变。近期，针对未服用过抗精神病药物的首发精神分裂症患者及匹配对照组的背侧前额叶皮质进行的活体磷-31核磁共振研究显示，其膜磷脂和能量代谢存在改变迹象。在精神分裂症患者中观察到的膜改变，要么与早衰相符，要么与正常脑发育过程中发生的退行性事件的时间改变和过度表现相符。这些分子变化可能在精神分裂症临床症状和脑结构变化出现之前就已发生，并为该疾病的发病机制和治疗提供了新的思路。
