病例报告：解硫胺素芽孢杆菌：一种人类感染的新病因，导致一名血液透析患者发生菌血症。
Case report: Paenibacillus thiaminolyticus: a new cause of human infection, inducing bacteremia in a patient on hemodialysis.
作者信息
Ouyang Jie, Pei Zhiheng, Lutwick Larry, Dalal Sharvari, Yang Liying, Cassai Nicholas, Sandhu Kuldip, Hanna Bruce, Wieczorek Rosemary L, Bluth Martin, Pincus Matthew R
机构信息
Department of Pathology, State University of New York, Downstate Medical Center, Brooklyn, NY 11209, USA.
出版信息
Ann Clin Lab Sci. 2008 Autumn;38(4):393-400.
Abstract
Paenibacilli are gram-positive, aerobic bacteria that are related to Bacilli but differ in the DNA encoding their 16S rRNA. Until recently, these organisms were not known to cause human disease. There are now several reports of human infection caused by a few members of this genus, most commonly by P. alvei. We report a human infection in a patient with a permacath for chronic hemodialysis who was found to have bacteremia caused by P. thiaminolyticus, which is an environmental bacterium that has never been found to cause human disease. We identified this bacterium by biochemical tests, cloning, sequencing the genomic DNA encoding its 16S rRNA, growth characteristics, and electron microscopic studies. This constitutes the first report of a human infection caused by this organism.
摘要
类芽孢杆菌是革兰氏阳性需氧菌，与芽孢杆菌相关，但在编码其16S rRNA的DNA方面有所不同。直到最近，人们还不知道这些微生物会导致人类疾病。现在有几篇关于该属少数成员引起人类感染的报道，最常见的是蜂房类芽孢杆菌。我们报告了一例慢性血液透析患者的人类感染病例，该患者使用长期留置导管，被发现患有由解硫胺素类芽孢杆菌引起的菌血症，解硫胺素类芽孢杆菌是一种从未被发现会导致人类疾病的环境细菌。我们通过生化试验、克隆、对编码其16S rRNA的基因组DNA进行测序、生长特性研究和电子显微镜研究鉴定了这种细菌。这是该生物体引起人类感染的首例报告。
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