Karathanasis Nikolaos V, Choumerianou Despoina M, Kalmanti Maria
Department of Pediatrics, University Hospital of Heraklion, University of Crete, Heraklion, Crete, Greece.
Pediatr Blood Cancer. 2009 Mar;52(3):318-23. doi: 10.1002/pbc.21825.
Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children. Inherited predisposition and exposure to exogenous leukemogenic agents have been investigated as potential risk factors. Current therapy results in 5-year event-free survival exceeding 80% in children in developed countries. Predisposition to ALL and event-free outcome seems to be influenced by polymorphisms on genes involved in several metabolic pathways. The purpose of this review is to discuss the findings of different studies upon the role of gene polymorphisms in childhood ALL.
急性淋巴细胞白血病（ALL）是儿童中最常见的恶性肿瘤。遗传易感性和接触外源性致白血病因子已作为潜在危险因素进行了研究。目前的治疗使发达国家儿童的5年无事件生存率超过80%。ALL的易感性和无事件结局似乎受到参与多种代谢途径的基因多态性的影响。本综述的目的是讨论不同研究关于基因多态性在儿童ALL中的作用的发现。
