Wu Shi-Biao, Zhao Yun, Fan Hui, Hu Ying-He, Hamann Mark T, Peng Jiang-Nan, Starks Courtney M, O'Neil-Johnson Mark, Hu Jin-Feng
Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai, P. R. China.
Planta Med. 2008 Dec;74(15):1812-7. doi: 10.1055/s-0028-1088326. Epub 2008 Nov 7.
In addition to twenty-nine known compounds, two new guaiane sesquiterpenes and two new furanocoumarins were isolated from the chloroform extract of the rhizomes of Notopterygium incisum. The new structures were elucidated by means of spectroscopic methods including 2 D NMR techniques and mass spectrometry to be 8 beta-acetoxy-4 alpha,6 alpha-dihydroxy-1 alpha,5 alpha( H)-guai-9-ene (incisumdiol A, 1), 4 alpha,6 alpha-dihydroxy-1 alpha,5 alpha( H)-guai-9-ene (incisumdiol B, 2), 5-[(2 E,5 Z)-7-hydroxy-3,7-dimethyl-2,5-octadienoxy]psoralene ( 3) and 5-[(2,5)-epoxy-3-hydroxy-3,7-dimethyl-6-octenoxy]psoralene ( 4).
除了29种已知化合物外，还从羌活根茎的氯仿提取物中分离出两种新的愈创木烷倍半萜和两种新的呋喃香豆素。通过包括二维核磁共振技术和质谱在内的光谱方法阐明了新结构，分别为8β-乙酰氧基-4α,6α-二羟基-1α,5α(H)-愈创-9-烯（羌活二醇A，1）、4α,6α-二羟基-1α,5α(H)-愈创-9-烯（羌活二醇B，2）、5-[(2E,5Z)-7-羟基-3,7-二甲基-2,5-辛二烯氧基]补骨脂素（3）和5-[(2,5)-环氧-3-羟基-3,7-二甲基-6-辛烯氧基]补骨脂素（4）。
