Hu Mingqian, Wang Jiongkun, Cai Jiye, Wu Yangzhe, Wang Xiaoping
Chemistry Department, Jinan University, Guangzhou 510632, China.
Sheng Wu Gong Cheng Xue Bao. 2008 Aug;24(8):1428-32. doi: 10.1016/s1872-2075(08)60064-3.
Atomic force microscope (AFM) was used to study biotoxicity of food preservative sodium benzoate (SB) at the single cellular level. Lymphocyte morphology and membrane ultrastructure treated with SB at different concentrations and time were analyzed visually. As compared to the normal lymphocyte, the cell morphology and membrane was significantly changed and its ultrastructure was also complicated. After treated with SB, the Rp-v, Rq, Ra and Z values were changed. The statistical analysis of lymphocytes after treated with SB was studied, and discussed its mechanism.
利用原子力显微镜（AFM）在单细胞水平上研究食品防腐剂苯甲酸钠（SB）的生物毒性。直观分析了不同浓度和时间的SB处理后的淋巴细胞形态和膜超微结构。与正常淋巴细胞相比，细胞形态和膜发生了显著变化，其超微结构也变得复杂。用SB处理后，Rp-v、Rq、Ra和Z值发生了变化。对SB处理后的淋巴细胞进行了统计分析，并探讨了其作用机制。
