Miyazawa Noriko, Okazaki Mitsuyo, Ohga Shoji
Department of Health and Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Gunma, Japan.
J Oleo Sci. 2008;57(12):675-81. doi: 10.5650/jos.57.675.
In this study, we examined the effects of Pleurotus nebrodensis on systolic blood pressure of spontaneously hypertensive rats. Single-dose and continuous-dose tests with sample diets made from the fruit body of the mushroom, P. nebrodensis were carried out on SHR and control rats. Sample diets included 6% dry powder of fruit body (6% dry powder), hot water extract, polysaccharide fraction, protein fraction, dialyzable fraction and non-dialyzable fraction. Polysaccharide and protein fractions were obtained by hot water extraction. The protein fraction was separated to the dialyzable fraction and non-dialyzable fraction by dialysis. In the single-dose test, protein fraction, hot water extract and polysaccharide fraction decreased systolic blood pressure. Blood pressure was lowered after administration for 2 h, and it returned to the pre-administration blood pressure after 48 h. In the continuous-dose test, spontaneously hypertensive rats were fed each of the diets for 16 weeks. The 6% dry powder group showed significantly inhibited elevation of blood pressure compared with the control group and there was no influence on total cholesterol and triglyceride levels. The non-dialyzable fraction showed suppression of increase in blood pressure from the start of the continuous oral administration. Effects on the rennin angiotensin system and renal function were also indicated. The antihypertensive action effect of P. nebrodensis can be expected to not only prevent but also to improve hypertension.
在本研究中，我们检测了白灵侧耳对自发性高血压大鼠收缩压的影响。用白灵侧耳子实体制成的样品饲料对自发性高血压大鼠（SHR）和对照大鼠进行了单剂量和连续剂量试验。样品饲料包括6%子实体干粉（6%干粉）、热水提取物、多糖组分、蛋白质组分、可透析组分和不可透析组分。多糖和蛋白质组分通过热水提取获得。蛋白质组分通过透析分离为可透析组分和不可透析组分。在单剂量试验中，蛋白质组分、热水提取物和多糖组分可降低收缩压。给药2小时后血压降低，48小时后恢复至给药前血压。在连续剂量试验中，给自发性高血压大鼠喂食每种饲料16周。与对照组相比，6%干粉组的血压升高受到显著抑制，且对总胆固醇和甘油三酯水平无影响。不可透析组分从连续口服给药开始就显示出对血压升高的抑制作用。还表明了其对肾素血管紧张素系统和肾功能的影响。白灵侧耳的降压作用不仅有望预防高血压，还能改善高血压。
