通过原位杂交将人类Rh血型基因结构定位到染色体区域1p34.3 - 1p36.1。
Localization of the human Rh blood group gene structure to chromosome region 1p34.3-1p36.1 by in situ hybridization.
作者信息
Chérif-Zahar B, Mattéi M G, Le Van Kim C, Bailly P, Cartron J P, Colin Y
机构信息
INSERM U.76, Institut National de Transfusion Sanguine, Paris, France.
出版信息
Hum Genet. 1991 Feb;86(4):398-400. doi: 10.1007/BF00201843.
A cDNA clone, RhIXb (1384 bp), encoding the entire protein sequence of a human blood group Rh polypeptide has been used to map the Rh locus, by in situ hybridization, to the region p34.3-p36.1 of chromosome 1. Two other unrelated cDNA clones, pUCA2 (750 bp) and pUCIII (1600 bp), isolated during the cloning procedure of the Rh cDNA were investigated simultaneously, and assigned to chromosome 3p21.1-3p22 (clone pUCA2) and to chromosome 22q12.1-22q13.1 (clone pUCIII).
一个编码人类血型Rh多肽完整蛋白质序列的cDNA克隆RhIXb（1384碱基对），已通过原位杂交用于将Rh基因座定位到1号染色体的p34.3 - p36.1区域。在Rh cDNA克隆过程中分离出的另外两个不相关的cDNA克隆pUCA2（750碱基对）和pUCIII（1600碱基对）也同时进行了研究，并分别定位到3号染色体的p21.1 - 3p22（克隆pUCA2）和22号染色体的q12.1 - 22q13.1（克隆pUCIII）。
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