膜相关淋巴毒素/肿瘤坏死因子-β在人淋巴因子激活的杀伤细胞上的表达
Expression of membrane-associated lymphotoxin/tumor necrosis factor-beta on human lymphokine-activated killer cells.
作者信息
Abe Y, Miyake M, Horiuchi A, Kimura S, Hitsumoto Y
机构信息
Second Department of Surgery, Ehime University School of Medicine.
出版信息
Jpn J Cancer Res. 1991 Jan;82(1):23-6. doi: 10.1111/j.1349-7006.1991.tb01740.x.
Abstract
A membrane-associated lymphotoxin (LT)-related molecule was detected on human lymphokine-activated killer (LAK) cells by flow cytometric analysis. Kinetic analysis revealed that the LT antigenicity on LAK cells appeared at 9 h after the beginning of culture and was maintained thereafter. By autoradiography, the molecular weight of membrane LT was estimated to be 31 kD and/or 62 kD.
摘要
通过流式细胞术分析在人淋巴因子激活的杀伤（LAK）细胞上检测到一种与膜相关的淋巴毒素（LT）相关分子。动力学分析显示，LAK细胞上的LT抗原性在培养开始后9小时出现，并在之后持续存在。通过放射自显影法，膜LT的分子量估计为31 kD和/或62 kD。
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