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1
Expression of membrane-associated lymphotoxin/tumor necrosis factor-beta on human lymphokine-activated killer cells.膜相关淋巴毒素/肿瘤坏死因子-β在人淋巴因子激活的杀伤细胞上的表达
Jpn J Cancer Res. 1991 Jan;82(1):23-6. doi: 10.1111/j.1349-7006.1991.tb01740.x.
2
Correlation between killing activity towards the murine L929 cell line and expression of membrane-associated lymphotoxin-related molecule of human lymphokine-activated killer cells.人淋巴因子激活的杀伤细胞对小鼠L929细胞系的杀伤活性与膜相关淋巴毒素相关分子表达之间的相关性。
Eur J Immunol. 1992 Aug;22(8):2147-52. doi: 10.1002/eji.1830220828.
3
Transforming growth factor-beta 1 down-regulates expression of membrane-associated lymphotoxin and secretion of soluble lymphotoxin by human lymphokine-activated killer T cells in vitro.在体外，转化生长因子-β1可下调人淋巴因子激活的杀伤性T细胞中膜相关淋巴毒素的表达及可溶性淋巴毒素的分泌。
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4
Studies of membrane-associated and soluble (secreted) lymphotoxin in human lymphokine-activated T-killer cells in vitro.体外人淋巴因子激活的T杀伤细胞中膜相关及可溶性（分泌型）淋巴毒素的研究。
Lymphokine Cytokine Res. 1992 Apr;11(2):115-21.
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Enhancement of lymphokine-activated T killer cell tumor necrosis factor receptor mRNA transcription, tumor necrosis factor receptor membrane expression, and tumor necrosis factor/lymphotoxin release by IL-1 beta, IL-4, and IL-6 in vitro.白细胞介素-1β、白细胞介素-4和白细胞介素-6在体外增强淋巴因子激活的T杀伤细胞肿瘤坏死因子受体mRNA转录、肿瘤坏死因子受体膜表达以及肿瘤坏死因子/淋巴毒素释放。
J Immunol. 1991 Mar 1;146(5):1522-6.
6
Membrane-associated lymphotoxin expression and functional analysis of lymphokine-activated killer cells derived from tumor-infiltrating lymphocytes.膜相关淋巴毒素的表达及源自肿瘤浸润淋巴细胞的淋巴因子激活杀伤细胞的功能分析
Jpn J Cancer Res. 1993 Nov;84(11):1165-73. doi: 10.1111/j.1349-7006.1993.tb02817.x.
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Membrane-associated lymphotoxin-expressing lymphokine-activated killer cells up-regulate intercellular adhesion molecule-1 expression on target tumor cells in vitro.膜相关淋巴毒素表达的淋巴因子激活的杀伤细胞在体外上调靶肿瘤细胞上细胞间黏附分子-1的表达。
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75- but not 55-kDa tumor necrosis factor receptor is active in the homotypic aggregation and proliferation of human lymphokine-activated T killer (T-LAK) cells in vitro.75kDa而非55kDa的肿瘤坏死因子受体在体外人淋巴因子激活的T杀伤（T-LAK）细胞的同型聚集和增殖中具有活性。
J Leukoc Biol. 1995 Mar;57(3):462-8. doi: 10.1002/jlb.57.3.462.
9
Regulation of lymphokine-activated killer cell induction by human recombinant IL-1 receptor antagonist. Obligate paracrine pathway of IL-1 during lymphokine-activated killer cell induction.人重组白细胞介素-1受体拮抗剂对淋巴因子激活的杀伤细胞诱导的调节。白细胞介素-1在淋巴因子激活的杀伤细胞诱导过程中的专性旁分泌途径。
J Immunol. 1992 May 1;148(9):2941-6.
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Analysis of tumor necrosis factor and lymphotoxin secreted by incubation of lymphokine-activated killer cells with tumor cells.对淋巴因子激活的杀伤细胞与肿瘤细胞共同孵育后分泌的肿瘤坏死因子和淋巴毒素的分析。
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1
Operative stress potentiates the inductivity of membrane associated lymphotoxin (mLT) on lymphokine activated killer (LAK) cells in vitro.手术应激增强体外膜相关淋巴毒素（mLT）对淋巴因子激活的杀伤细胞（LAK）的诱导能力。
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2
Membrane-associated lymphotoxin expression and functional analysis of lymphokine-activated killer cells derived from tumor-infiltrating lymphocytes.膜相关淋巴毒素的表达及源自肿瘤浸润淋巴细胞的淋巴因子激活杀伤细胞的功能分析
Jpn J Cancer Res. 1993 Nov;84(11):1165-73. doi: 10.1111/j.1349-7006.1993.tb02817.x.
3
Role of membrane-associated lymphotoxin (mLT) in the killing activity of lymphokine-activated killer (LAK) cells towards various tumour cell lines.膜相关淋巴毒素（mLT）在淋巴因子激活的杀伤细胞（LAK细胞）对各种肿瘤细胞系的杀伤活性中的作用。
Clin Exp Immunol. 1994 Apr;96(1):152-7. doi: 10.1111/j.1365-2249.1994.tb06245.x.
4
The role of tumor necrosis factor receptors in cell signaling and the significance of soluble form levels in the serum.
Surg Today. 1994;24(3):197-202. doi: 10.1007/BF02032887.

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Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells.培养的人骨髓瘤细胞产生骨吸收细胞因子淋巴毒素。
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Membrane-associated interleukin 1 activity on human U937 tumor cells: stimulation of PGE2 production by human chondrosarcoma cells.人U937肿瘤细胞上与膜相关的白细胞介素1活性：人软骨肉瘤细胞对前列腺素E2产生的刺激作用。
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A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone.关于使用淋巴因子激活的杀伤细胞和白细胞介素-2或单独使用高剂量白细胞介素-2治疗157例晚期癌症患者的进展报告。
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Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.细胞相关肿瘤坏死因子（TNF）作为活化细胞毒性巨噬细胞的一种杀伤机制。
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A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF.一种新型的肿瘤坏死因子/恶病质素是一种细胞表面细胞毒性跨膜蛋白：对肿瘤坏死因子复杂生理学的影响。
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膜相关淋巴毒素/肿瘤坏死因子-β在人淋巴因子激活的杀伤细胞上的表达

Expression of membrane-associated lymphotoxin/tumor necrosis factor-beta on human lymphokine-activated killer cells.

作者信息

Abe Y, Miyake M, Horiuchi A, Kimura S, Hitsumoto Y

机构信息

Second Department of Surgery, Ehime University School of Medicine.

出版信息

Jpn J Cancer Res. 1991 Jan;82(1):23-6. doi: 10.1111/j.1349-7006.1991.tb01740.x.

DOI:10.1111/j.1349-7006.1991.tb01740.x
PMID:1900262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918213/
Abstract

A membrane-associated lymphotoxin (LT)-related molecule was detected on human lymphokine-activated killer (LAK) cells by flow cytometric analysis. Kinetic analysis revealed that the LT antigenicity on LAK cells appeared at 9 h after the beginning of culture and was maintained thereafter. By autoradiography, the molecular weight of membrane LT was estimated to be 31 kD and/or 62 kD.

摘要

通过流式细胞术分析在人淋巴因子激活的杀伤（LAK）细胞上检测到一种与膜相关的淋巴毒素（LT）相关分子。动力学分析显示，LAK细胞上的LT抗原性在培养开始后9小时出现，并在之后持续存在。通过放射自显影法，膜LT的分子量估计为31 kD和/或62 kD。