Mega Seiji, Oguri Mitsuru, Kawasaki Ryosuke, Hazama Kazuaki, Iwai Kazuhiro, Kondo Satoshi
Division of Surgery, Oji General Hospital, 3-4-8 Wakakusachyo, Tomakomai, Hokkaido 053-8506, Japan.
Gen Thorac Cardiovasc Surg. 2008 Nov;56(11):566-9. doi: 10.1007/s11748-008-0299-7. Epub 2008 Nov 12.
Large-cell neuroendocrine carcinoma in the thymus is a rare cancer that is more aggressive and leads to a poorer prognosis than other thymic epithelial tumors. A 67-year-old woman presented with an anterior mediastinal mass in the thymus. Histological examination after thymectomy revealed large-cell neuroendocrine carcinoma in the thymus. Although the patient received postoperative chemotherapy and radiotherapy, a distant relapse was detected 6 months after the surgery. We reviewed nine cases of this rare cancer that have been reported in Japan. There is no evidence of to support postoperative therapy for large-cell neuroendocrine carcinoma in the thymus. However, it is essential to accumulate and study these cases to understand this disease and prolong patient survival.
胸腺大细胞神经内分泌癌是一种罕见的癌症，与其他胸腺上皮肿瘤相比，其侵袭性更强，预后更差。一名67岁女性因胸腺前纵隔肿块就诊。胸腺切除术后的组织学检查显示为胸腺大细胞神经内分泌癌。尽管患者接受了术后化疗和放疗，但术后6个月仍检测到远处复发。我们回顾了日本报道的9例这种罕见癌症。目前尚无证据支持胸腺大细胞神经内分泌癌的术后治疗。然而，积累和研究这些病例对于了解这种疾病和延长患者生存期至关重要。
