Centro di Ricerca E. Menni, Fondazione Poliambulanza - Istituto Ospedaliero, Via Bissolati, 57, 25124, Brescia, Italy.
Cytotechnology. 2008 Sep;58(1):33-42. doi: 10.1007/s10616-008-9162-z. Epub 2008 Sep 28.
An urgent current need in regenerative medicine is that of identifying a plentiful, safe and ethically acceptable stem cell source for the development of therapeutic strategies to restore functionality in damaged or diseased organs and tissues. In this context, human term placenta represents a prime candidate, as it is available in nearly unlimited supply, is ethically problem-free and easily procured. Placental cells display differentiation capacity toward all three germ layers, while also displaying immunomodulatory effects, therefore supporting the possibility that they could be applied in an allogeneic transplantation setting. Although promising data have been reported to date, further study is required to fully characterize the differentiation potential of placenta-derived cells and to identify their possible clinical applications. Here, we provide a snapshot of current knowledge regarding the potential of cells from the amniotic membrane of human term placenta to address current shortcomings in the field of regenerative medicine.
再生医学目前急需找到一种丰富、安全且符合伦理道德的干细胞来源，以开发治疗策略来恢复受损或患病器官和组织的功能。在这种情况下，人类足月胎盘是一个主要的候选物，因为它几乎可以无限供应，不存在伦理问题，并且易于获取。胎盘细胞具有向三个胚层分化的能力，同时还具有免疫调节作用，因此支持它们可以应用于同种异体移植的可能性。尽管迄今为止已经有了有希望的数据报告，但仍需要进一步研究来充分表征胎盘来源细胞的分化潜力，并确定它们可能的临床应用。在这里，我们提供了关于人类足月胎盘羊膜细胞潜力的当前知识的快照，以解决再生医学领域的当前不足。
