Deus Inês A, Mano João F, Custódio Catarina A
CICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
CICECO, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
Acta Biomater. 2020 Jul 1;110:1-14. doi: 10.1016/j.actbio.2020.04.035. Epub 2020 May 14.
Perinatal tissues are an abundant source of human extracellular matrix proteins, growth factors and stem cells with proved potential use in a wide range of therapeutic applications. Due to their placental origin, these tissues possess unique biological properties, including being angiogenic, anti-inflammatory, anti-fibrotic, anti-microbial and immune privileged. Additionally, as a temporary organ, placenta is usually discarded as a medical waste, thus providing an easily available, cost effective, 'unlimited' and ethical source of raw materials. Although some of these tissues, such as the amniotic membrane and umbilical cord, have been used in clinical practices, most of them continue to be highly under explored. This review aims to outline the most relevant applications of perinatal tissues as a source of biomaterials and stem cells in the exciting fields of tissue engineering and regenerative medicine (TERM), as well as highlight how these solutions can be used to overcome the shortage of adequate scaffolds and cell sources that currently hampers the translation of TERM strategies towards clinical settings. STATEMENT OF SIGNIFICANCE: Stem cells and extracellular matrix derived from perinatal tissues such as placenta and umbilical cord, have drawn great attention for use in a wide variety of applications in the biomedical field. Due to their origin, these tissues possess unique biological properties, including being angiogenic, anti-inflammatory, anti-fibrotic, anti-microbial and immune privileged. Also they are typically considered medical waste, thus providing an easily available, cost effective, 'unlimited' and ethical source of raw materials. This work aims to present and discuss the most relevant applications of perinatal tissues as a source of biomaterials and stem cells in the exciting fields of tissue engineering and regenerative medicine (TERM).
围产期组织是人类细胞外基质蛋白、生长因子和干细胞的丰富来源，已证明其在广泛的治疗应用中具有潜在用途。由于其胎盘来源，这些组织具有独特的生物学特性，包括具有血管生成、抗炎、抗纤维化、抗菌和免疫特权。此外，作为一个临时器官，胎盘通常作为医疗废物被丢弃，从而提供了一种易于获得、成本效益高、“无限”且符合伦理的原材料来源。尽管其中一些组织，如羊膜和脐带，已被用于临床实践，但大多数组织仍有待深入探索。本综述旨在概述围产期组织作为生物材料和干细胞来源在组织工程和再生医学（TERM）这一令人兴奋的领域中的最相关应用，并强调这些解决方案如何用于克服目前阻碍TERM策略转化为临床应用的合适支架和细胞来源短缺的问题。重要性声明：源自胎盘和脐带等围产期组织的干细胞和细胞外基质在生物医学领域的各种应用中受到了极大关注。由于其来源，这些组织具有独特的生物学特性，包括具有血管生成、抗炎、抗纤维化、抗菌和免疫特权。而且它们通常被视为医疗废物，从而提供了一种易于获得、成本效益高、“无限”且符合伦理的原材料来源。这项工作旨在介绍和讨论围产期组织作为生物材料和干细胞来源在组织工程和再生医学（TERM）这一令人兴奋的领域中的最相关应用。
