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Cytotechnology. 2003 Nov;43(1-3):145-8. doi: 10.1023/b:cyto.0000039896.26707.40.
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The effects of thyme volatiles on the induction of DNA damage by the heterocyclic amine IQ and mitomycin C.
Mutat Res. 2005 Mar 7;581(1-2):43-53. doi: 10.1016/j.mrgentox.2004.10.017. Epub 2005 Jan 15.
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Investigation of the antimutagenic effects of selected South African medicinal plant extracts.南非选定药用植物提取物抗诱变作用的研究。
Toxicol In Vitro. 2004 Feb;18(1):29-35. doi: 10.1016/s0887-2333(03)00131-0.
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Genotoxicity of pesticides: a review of human biomonitoring studies.农药的遗传毒性：人体生物监测研究综述
Mutat Res. 2003 Jun;543(3):251-72. doi: 10.1016/s1383-5742(03)00015-2.
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Ascorbic acid potentiates mitomycin C-induced micronuclei and sister chromatid exchanges in human peripheral blood lymphocytes in vitro.体外实验中，抗坏血酸可增强丝裂霉素C诱导的人外周血淋巴细胞微核形成及姐妹染色单体交换。
Teratog Carcinog Mutagen. 2003;Suppl 1:99-112. doi: 10.1002/tcm.10064.
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Inhibitory effect of chamomile essential oil on the sister chromatid exchanges induced by daunorubicin and methyl methanesulfonate in mouse bone marrow.
Toxicol Lett. 2002 Sep 5;135(1-2):103-110. doi: 10.1016/s0378-4274(02)00253-9.
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Toxicity of selected plant volatiles in microbial and mammalian short-term assays.在微生物和哺乳动物短期试验中所选植物挥发物的毒性
Food Chem Toxicol. 1999 Aug;37(8):813-23. doi: 10.1016/s0278-6915(99)00075-7.
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Chromosomal aberrations in lymphocytes predict human cancer: a report from the European Study Group on Cytogenetic Biomarkers and Health (ESCH).淋巴细胞中的染色体畸变可预测人类癌症：欧洲细胞遗传学生物标志物与健康研究小组（ESCH）的报告。
Cancer Res. 1998 Sep 15;58(18):4117-21.
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Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay.
Arch Environ Contam Toxicol. 1995 Feb;28(2):248-58. doi: 10.1007/BF00217624.
10
The action of three anticlastogens on the induction of sister chromatid exchange by trenimon and 8-hydroxyquinoline sulfate in human lymphocyte cultures.三种抗断裂剂对人淋巴细胞培养物中曲尼司特和硫酸8-羟基喹啉诱导的姐妹染色单体交换的作用。
Environ Mutagen. 1980;2(2):191-200. doi: 10.1002/em.2860020212.

毛诃子变种薄叶变种提取物对丝裂霉素 C 诱导的人淋巴细胞染色体畸变和姐妹染色单体交换的影响。

Effects of Thymus kotschyanus var. glabrescens Boiss. extract on mitomycin-C induced chromosomal aberrations and sister chromatid exchanges in human lymphocytes.

机构信息

Science Faculty, Department of Biology, Kahramanmaraş Sütcü Imam University, 46100, Kahramanmaraş, Türkiye.

出版信息

Cytotechnology. 2006 Jun;51(2):99-104. doi: 10.1007/s10616-006-9015-6. Epub 2006 Sep 21.

DOI:10.1007/s10616-006-9015-6
PMID:19002900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3449678/
Abstract

In this investigation, clastogenic effects of Thymus kotschyanus var. glabrescens Boiss. extract (TE) and anticlastogenic effects of this extract against Mitomycin C (MMC) induced chromosome damage have been evaluated in human peripheral blood lymphocytes in vitro. Two series of experiments were conducted. In the first, only 10(-5), 10(-4), 10(-3) and 10(-2) mul ml(-1) concentrations of TE were used for 48 h to detect potential clastogenicity. In the second, MMC (0.38 mug ml(-1)) plus 10(-5), 10(-4), 10(-3) and 10(-2) mul ml(-1) concentrations of TE were used for 48 h to determine anticlastogenic effects. TE did not increase sister chromatid exchanges (SCEs) (except 10(-2) mul ml concentration) and chromosome aberrations (CAs) significantly compared with negative and solvent controls. However, it decreased the frequency of MMC induced chromosome aberrations. Decreasing was significant at 10(-4), 10(-3) and 10(-2) mul ml(-1) concentrations. On the other hand, TE significantly increased MMC-induced SCEs for all treatment groups compared with positive control.

摘要

在这项研究中，我们评估了 Thymus kotschyanus var. glabrescens Boiss. 提取物（TE）的致裂效应和该提取物对丝裂霉素 C（MMC）诱导的染色体损伤的抗致裂效应，采用人外周血淋巴细胞体外实验。进行了两个系列的实验。在第一个实验中，仅使用 10(-5)、10(-4)、10(-3)和 10(-2)mul ml(-1)浓度的 TE 处理 48 小时，以检测潜在的致裂性。在第二个实验中，使用 MMC（0.38 mug ml(-1))和 10(-5)、10(-4)、10(-3)和 10(-2)mul ml(-1)浓度的 TE 处理 48 小时，以确定抗致裂效应。与阴性和溶剂对照组相比，TE 并没有显著增加姐妹染色单体交换（SCEs）（除 10(-2)mul ml 浓度外）和染色体畸变（CAs）的频率。然而，它降低了 MMC 诱导的染色体畸变的频率。在 10(-4)、10(-3)和 10(-2)mul ml(-1)浓度下降低效果显著。另一方面，与阳性对照组相比，TE 显著增加了所有处理组中 MMC 诱导的 SCEs。