香芹酚对人淋巴细胞姐妹染色单体交换的影响。
Effects of carvacrol on sister chromatid exchanges in human lymphocyte cultures.
机构信息
Department of Biology, Anadolu University, Faculty of Sciences, Yunusemre Campus, 26470, Eskisehir, Turkey.
出版信息
Cytotechnology. 2003 Nov;43(1-3):145-8. doi: 10.1023/b:cyto.0000039896.26707.40.
Abstract
Carvacrol is a predominant aromatic compound in oil of oregano. It has naturally remarkable antibacterial, antiviral, antifungal and antiparasital effects. In this study, genotoxic and antigenotoxic activities of carvacrol were investigated by the in vitro sister chromatid exchange (SCE) assay on human peripheral blood lymphocytes. The genotoxicity test was performed with carvacrol in two donors. On the other hand, inhibitory effect of carvacrol was tested in the presence of mitomycin C (MMC) in the same assay. According to data, all doses of carvacrol did not increase the formation of SCE, whereas it inhibited the rate of SCE induced by MMC. In conclusion, carvacrol exhibited a significant antigenotoxic activity in mammalian cells, indicating its potential for use as an antigenotoxic agent.
摘要
香芹酚是牛至油中的主要芳香化合物。它具有天然的显著抗菌、抗病毒、抗真菌和抗寄生虫作用。在这项研究中，通过体外姐妹染色单体交换（SCE）试验研究了香芹酚的遗传毒性和抗原毒性作用在人外周血淋巴细胞中。在两名供体中进行了香芹酚的遗传毒性试验。另一方面，在相同的试验中测试了香芹酚对丝裂霉素 C（MMC）的抑制作用。根据数据，香芹酚的所有剂量均未增加 SCE 的形成，而抑制了 MMC 诱导的 SCE 率。总之，香芹酚在哺乳动物细胞中表现出显著的抗原毒性活性，表明其具有作为抗原毒性剂的潜力。
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