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本文引用的文献

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Inhibition of Growth of Mycotoxigenic Fusarium Species by Butylated Hydroxyanisole and/or Carvacrol.叔丁基对苯二酚和/或香芹酚对产毒镰刀菌属物种生长的抑制作用
J Food Prot. 1996 Apr;59(4):412-415. doi: 10.4315/0362-028X-59.4.412.
2
Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene.香芹酚对携带人类N-RAS癌基因的小鼠成肌细胞中DNA合成的抑制作用。
Phytomedicine. 2003 May;10(4):292-9. doi: 10.1078/094471103322004785.
3
The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus.香芹酚的酚羟基对于抵抗食源性病原体蜡样芽孢杆菌的作用至关重要。
Appl Environ Microbiol. 2002 Apr;68(4):1561-8. doi: 10.1128/AEM.68.4.1561-1568.2002.
4
Influence of carvacrol on growth and toxin production by Bacillus cereus.香芹酚对蜡样芽孢杆菌生长及毒素产生的影响。
Int J Food Microbiol. 2001 Mar 20;64(3):373-8. doi: 10.1016/s0168-1605(00)00480-3.
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Toxicity of selected plant volatiles in microbial and mammalian short-term assays.在微生物和哺乳动物短期试验中所选植物挥发物的毒性
Food Chem Toxicol. 1999 Aug;37(8):813-23. doi: 10.1016/s0278-6915(99)00075-7.
6
Bactericidal activity of carvacrol towards the food-borne pathogen Bacillus cereus.香芹酚对食源性病原体蜡样芽孢杆菌的杀菌活性。
J Appl Microbiol. 1998 Aug;85(2):211-8. doi: 10.1046/j.1365-2672.1998.00467.x.
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Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo.类异戊二烯在体外和体内均能抑制小鼠B16黑色素瘤的生长。
J Nutr. 1997 May;127(5):668-74. doi: 10.1093/jn/127.5.668.
8
Activity of thymol, carvacrol, cinnamaldehyde and eugenol on oral bacteria.百里香酚、香芹酚、肉桂醛和丁香酚对口腔细菌的活性。
Pharm Acta Helv. 1994 Jul;69(1):25-8. doi: 10.1016/0031-6865(94)90027-2.
9
Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol.百里香酚、香芹酚、6-姜酚、姜酮和羟基酪醇的抗氧化作用。
Food Chem Toxicol. 1994 Jan;32(1):31-6. doi: 10.1016/0278-6915(84)90033-4.
10
Food flavourings and compounds of related structure. II. Subacute and chronic toxicity.食品调味剂及相关结构的化合物。II. 亚急性和慢性毒性。
Food Cosmet Toxicol. 1967 Apr;5(2):141-57. doi: 10.1016/s0015-6264(67)82961-4.

香芹酚对人淋巴细胞姐妹染色单体交换的影响。

Effects of carvacrol on sister chromatid exchanges in human lymphocyte cultures.

机构信息

Department of Biology, Anadolu University, Faculty of Sciences, Yunusemre Campus, 26470, Eskisehir, Turkey.

出版信息

Cytotechnology. 2003 Nov;43(1-3):145-8. doi: 10.1023/b:cyto.0000039896.26707.40.

DOI:10.1023/b:cyto.0000039896.26707.40
PMID:19003219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3449596/
Abstract

Carvacrol is a predominant aromatic compound in oil of oregano. It has naturally remarkable antibacterial, antiviral, antifungal and antiparasital effects. In this study, genotoxic and antigenotoxic activities of carvacrol were investigated by the in vitro sister chromatid exchange (SCE) assay on human peripheral blood lymphocytes. The genotoxicity test was performed with carvacrol in two donors. On the other hand, inhibitory effect of carvacrol was tested in the presence of mitomycin C (MMC) in the same assay. According to data, all doses of carvacrol did not increase the formation of SCE, whereas it inhibited the rate of SCE induced by MMC. In conclusion, carvacrol exhibited a significant antigenotoxic activity in mammalian cells, indicating its potential for use as an antigenotoxic agent.

摘要

香芹酚是牛至油中的主要芳香化合物。它具有天然的显著抗菌、抗病毒、抗真菌和抗寄生虫作用。在这项研究中，通过体外姐妹染色单体交换（SCE）试验研究了香芹酚的遗传毒性和抗原毒性作用在人外周血淋巴细胞中。在两名供体中进行了香芹酚的遗传毒性试验。另一方面，在相同的试验中测试了香芹酚对丝裂霉素 C（MMC）的抑制作用。根据数据，香芹酚的所有剂量均未增加 SCE 的形成，而抑制了 MMC 诱导的 SCE 率。总之，香芹酚在哺乳动物细胞中表现出显著的抗原毒性活性，表明其具有作为抗原毒性剂的潜力。