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Murine Peyer's patch dendritic cells prime naïve CD4(+) T cells to produce interferon-gamma.鼠派尔斑树突状细胞将初始 CD4(+)T 细胞致敏以产生干扰素-γ。
Cytotechnology. 2002 Nov;40(1-3):31-8. doi: 10.1023/A:1023949620172.
2
Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells.新鲜分离的派尔集合淋巴结而非脾脏的树突状细胞可产生白细胞介素10，并诱导2型辅助性T细胞分化。
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CD11b+ Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells.CD11b+派尔集合淋巴结树突状细胞分泌白细胞介素-6并诱导初始B细胞分泌免疫球蛋白A。
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Splenic dendritic cells pulsed with Ixodes ricinus tick saliva prime naive CD4+T to induce Th2 cell differentiation in vitro and in vivo.用蓖麻硬蜱唾液脉冲处理的脾树突状细胞在体外和体内使初始CD4 + T细胞致敏，以诱导Th2细胞分化。
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Cytotechnology. 2003 Nov;43(1-3):49-55. doi: 10.1023/b:cyto.0000039906.15156.cd.

本文引用的文献

1
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.B7-DC，一种对T细胞具有强大共刺激特性的新型树突状细胞分子。
J Exp Med. 2001 Apr 2;193(7):839-46. doi: 10.1084/jem.193.7.839.
2
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.新型p19蛋白与IL-12p40结合形成一种细胞因子IL-23，其生物学活性与IL-12相似但又有所不同。
Immunity. 2000 Nov;13(5):715-25. doi: 10.1016/s1074-7613(00)00070-4.
3
Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine.不同派尔集合淋巴结树突状细胞亚群的定位及其被趋化因子巨噬细胞炎性蛋白（MIP）-3α、MIP-3β和次级淋巴器官趋化因子募集的情况
J Exp Med. 2000 Apr 17;191(8):1381-94. doi: 10.1084/jem.191.8.1381.
4
Role of CD8alpha+ and CD8alpha- dendritic cells in the induction of primary immune responses in vivo.CD8α⁺和CD8α⁻树突状细胞在体内诱导初始免疫反应中的作用。
J Leukoc Biol. 1999 Aug;66(2):242-6. doi: 10.1002/jlb.66.2.242.
5
Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells.新鲜分离的派尔集合淋巴结而非脾脏的树突状细胞可产生白细胞介素10，并诱导2型辅助性T细胞分化。
J Exp Med. 1999 Jul 19;190(2):229-39. doi: 10.1084/jem.190.2.229.
6
Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells.CD8α⁺淋巴样树突状细胞依赖白细胞介素12产生γ干扰素。
J Exp Med. 1999 Jun 21;189(12):1981-6. doi: 10.1084/jem.189.12.1981.
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Dendritic cells and the control of immunity.树突状细胞与免疫调控
Nature. 1998 Mar 19;392(6673):245-52. doi: 10.1038/32588.
8
Gamma interferon induces Fas-dependent apoptosis of Peyer's patch T cells in mice following peroral infection with Toxoplasma gondii.γ干扰素在小鼠经口感染刚地弓形虫后可诱导派尔集合淋巴结T细胞发生Fas依赖性凋亡。
Infect Immun. 1997 Nov;65(11):4682-9. doi: 10.1128/iai.65.11.4682-4689.1997.
9
Differential effects of LPS and CD40 ligand stimulations on the induction of IL-12 production by dendritic cells and macrophages.脂多糖（LPS）和CD40配体刺激对树突状细胞和巨噬细胞诱导产生白细胞介素-12的不同影响。
Cell Immunol. 1997 Oct 10;181(1):59-67. doi: 10.1006/cimm.1997.1196.
10
Salmonella typhimurium infections in mice deficient in interleukin-4 production: role of IL-4 in infection-associated pathology.白细胞介素-4产生缺陷的小鼠中的鼠伤寒沙门氏菌感染：IL-4在感染相关病理中的作用
J Immunol. 1997 Aug 15;159(4):1820-7.

鼠派尔斑树突状细胞将初始 CD4(+)T 细胞致敏以产生干扰素-γ。

Murine Peyer's patch dendritic cells prime naïve CD4(+) T cells to produce interferon-gamma.

机构信息

Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan.

出版信息

Cytotechnology. 2002 Nov;40(1-3):31-8. doi: 10.1023/A:1023949620172.

DOI:10.1023/A:1023949620172
PMID:19003102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3449535/
Abstract

We investigated the role of Peyer's patch (PP) dendritic cells (DCs) in the production of interferon (IFN)-gamma from naïve CD4(+) T cells of T cell receptor transgenic mice. PP DCs were found to prime naïve CD4(+) T cells for the production of higher levels of IFN-gamma, when compared to spleen (SP) DCs. However, a similar level of interleukin-12 (IL-12) production was observed for PP and SP DCs stimulated via the CD40 molecule. In addition, PP DCs expressed slightly higher levels of B7.2 (CD86) compared to SP DCs. This data demonstrates that PP DCs have a distinct function in the induction of IFN-gammas and suggests that PP DCs may enhance IFN-gamma production via another cytokine or costimulatory molecule, in addition to IL-12.

摘要

我们研究了派尔集合淋巴结（PP）树突状细胞（DC）在产生干扰素（IFN）-γ中的作用，这些细胞来自于 T 细胞受体转基因小鼠的幼稚 CD4(+)T 细胞。与脾（SP）DC 相比，PP DC 能够刺激幼稚 CD4(+)T 细胞产生更高水平的 IFN-γ。然而，对于通过 CD40 分子刺激的 PP 和 SP DC，观察到类似水平的白细胞介素-12（IL-12）产生。此外，PP DC 表达的 B7.2（CD86）比 SP DC 略高。这些数据表明 PP DC 在诱导 IFN-γ的产生方面具有独特的功能，并表明除了 IL-12 之外，PP DC 可能通过另一种细胞因子或共刺激分子增强 IFN-γ的产生。