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1
Interleukin 12 and CD86 Regulate Th1 and Th2 Development Induced by a Range of Antigen Doses Presented by Peyer's Patch and Spleen Cells.白细胞介素 12 和 CD86 调节由派尔集合淋巴结和脾脏细胞呈递的一系列抗原剂量诱导的 Th1 和 Th2 发育。
Cytotechnology. 2003 Nov;43(1-3):81-8. doi: 10.1023/b:cyto.0000039895.11048.1b.
2
Antigen presentation by Peyer's patch cells can induce both Th1- and Th2-type responses depending on antigen dosage, but a different cytokine response pattern from that of spleen cells.派尔集合淋巴结细胞的抗原呈递可根据抗原剂量诱导Th1型和Th2型反应，但细胞因子反应模式与脾细胞不同。
Biosci Biotechnol Biochem. 2002 May;66(5):963-9. doi: 10.1271/bbb.66.963.
3
Selective induction of Th2 cells in murine Peyer's patches by oral immunization.通过口服免疫在小鼠派尔集合淋巴结中选择性诱导Th2细胞。
Int Immunol. 1992 Apr;4(4):433-45. doi: 10.1093/intimm/4.4.433.
4
Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei.对益生菌干酪乳杆菌 Peyer 斑细胞的炎症细胞因子反应的良好控制。
Immunology. 2010 Jul;130(3):352-62. doi: 10.1111/j.1365-2567.2009.03204.x.
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Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.参与免疫球蛋白A应答的辅助性T细胞亚群：以破伤风类毒素和霍乱毒素作为佐剂进行口服免疫，可在黏膜相关组织中选择性诱导Th2细胞。
J Exp Med. 1993 Oct 1;178(4):1309-20. doi: 10.1084/jem.178.4.1309.
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Dendritic cells from Peyer's patch and spleen induce different T helper cell responses.派尔集合淋巴结和脾脏中的树突状细胞可诱导不同的辅助性T细胞反应。
J Interferon Cytokine Res. 1998 Feb;18(2):103-15. doi: 10.1089/jir.1998.18.103.
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Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells.新鲜分离的派尔集合淋巴结而非脾脏的树突状细胞可产生白细胞介素10，并诱导2型辅助性T细胞分化。
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The liquid culture filtrates of Paecilomyces tenuipes (Peck) Samson (=Isaria japonica Yasuda) and Paecilomyces cicadae (Miquel) Samson (=Isaria sinclairii (Berk.) Llond) regulate Th1 and Th2 cytokine response in murine Peyer's patch cells in vitro and ex vivo.细脚拟青霉（Peck）Samson（=日本棒束孢Yasuda）和蝉拟青霉（Miquel）Samson（=辛克莱棒束孢（Berk.）Llond）的液体培养滤液在体外和体内均能调节小鼠派伊尔结细胞中Th1和Th2细胞因子的反应。
Int Immunopharmacol. 2005 May;5(5):903-16. doi: 10.1016/j.intimp.2005.01.005.
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Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation.TCR信号的强度决定了Th1和Th2 CD4 + T细胞分化所需的共刺激条件。
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Dendritic Cells from Spleen, Mesenteric Lymph Node and Peyer's Patch Can Induce the Production of Both IL-4 and IFN-gamma from Primary Cultures of Naive CD4(+) T Cells in a Dose-Dependent Manner.脾、肠系膜淋巴结和派尔集合淋巴结的树突状细胞可在剂量依赖性方式下诱导初始 CD4(+) T 细胞培养物中产生 IL-4 和 IFN-γ。
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Rhipicephalus microplus salivary gland molecules induce differential CD86 expression in murine macrophages.微小扇头蜱唾液腺分子诱导小鼠巨噬细胞中CD86表达差异。
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本文引用的文献

1
Antigen presentation by Peyer's patch cells can induce both Th1- and Th2-type responses depending on antigen dosage, but a different cytokine response pattern from that of spleen cells.派尔集合淋巴结细胞的抗原呈递可根据抗原剂量诱导Th1型和Th2型反应，但细胞因子反应模式与脾细胞不同。
Biosci Biotechnol Biochem. 2002 May;66(5):963-9. doi: 10.1271/bbb.66.963.
2
Naive CD4+ T cells exhibit distinct expression patterns of cytokines and cell surface molecules on their primary responses to varying doses of antigen.初始CD4 + T细胞在对不同剂量抗原的初次反应中表现出细胞因子和细胞表面分子的不同表达模式。
J Immunol. 2002 Apr 1;168(7):3242-50. doi: 10.4049/jimmunol.168.7.3242.
3
Regulation of Th1/Th2 development by antigen-presenting cells in vivo.体内抗原呈递细胞对Th1/Th2细胞发育的调控。
Immunobiology. 2001 Dec;204(5):551-7. doi: 10.1078/0171-2985-00092.
4
Interleukin-10-secreting Peyer's patch cells are responsible for active suppression in low-dose oral tolerance.分泌白细胞介素-10的派尔集合淋巴结细胞负责低剂量口服耐受中的主动抑制。
Immunology. 2001 Aug;103(4):458-64. doi: 10.1046/j.1365-2567.2001.01265.x.
5
Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer's patch dendritic cells.CD11b+、CD8α+和双阴性派尔集合淋巴结树突状细胞的独特功能。
J Immunol. 2001 Apr 15;166(8):4884-90. doi: 10.4049/jimmunol.166.8.4884.
6
The antigen dose determines T helper subset development by regulation of CD40 ligand.抗原剂量通过调节CD40配体来决定辅助性T细胞亚群的发育。
Eur J Immunol. 2000 Jul;30(7):2056-64. doi: 10.1002/1521-4141(200007)30:7<2056::AID-IMMU2056>3.0.CO;2-S.
7
Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine.不同派尔集合淋巴结树突状细胞亚群的定位及其被趋化因子巨噬细胞炎性蛋白（MIP）-3α、MIP-3β和次级淋巴器官趋化因子募集的情况
J Exp Med. 2000 Apr 17;191(8):1381-94. doi: 10.1084/jem.191.8.1381.
8
CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen.CD28、Ox-40、淋巴细胞功能相关抗原-1（LFA-1）以及CD4对Th1/Th2分化的调节直接取决于抗原剂量。
J Immunol. 2000 Mar 15;164(6):2955-63. doi: 10.4049/jimmunol.164.6.2955.
9
Primary response of naive CD4(+) T cells to amino acid-substituted analogs of an antigenic peptide can show distinct activation patterns: Th1- and Th2-type cytokine secretion, and helper activity for antibody production without apparent cytokine secretion.初始CD4(+) T细胞对抗原肽氨基酸取代类似物的初次反应可呈现不同的激活模式：Th1型和Th2型细胞因子分泌，以及在无明显细胞因子分泌情况下对抗体产生的辅助活性。
FEBS Lett. 2000 Jan 7;465(1):28-33. doi: 10.1016/s0014-5793(99)01716-0.
10
Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells.新鲜分离的派尔集合淋巴结而非脾脏的树突状细胞可产生白细胞介素10，并诱导2型辅助性T细胞分化。
J Exp Med. 1999 Jul 19;190(2):229-39. doi: 10.1084/jem.190.2.229.

白细胞介素 12 和 CD86 调节由派尔集合淋巴结和脾脏细胞呈递的一系列抗原剂量诱导的 Th1 和 Th2 发育。

Interleukin 12 and CD86 Regulate Th1 and Th2 Development Induced by a Range of Antigen Doses Presented by Peyer's Patch and Spleen Cells.

机构信息

Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, 113-8657, Japan.

出版信息

Cytotechnology. 2003 Nov;43(1-3):81-8. doi: 10.1023/b:cyto.0000039895.11048.1b.

DOI:10.1023/b:cyto.0000039895.11048.1b
PMID:19003211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3449607/
Abstract

In this study, we demonstrate the role of interleukin 12 (IL-12), CD80 and CD86 in T helper type 1 (Th1) and Th2 differentiation induced through antigen presentation by Peyer's patch (PP) and spleen (SPL) cells with various doses of antigen. IL-12 was found to be critical for the induction of Th1-type cytokine producing cells, while antigen-dose dependent patterns of differentiation into Th2-type cytokine producing cells were not altered by the blockade of IL-12. Further, the difference in the pattern of Th2-type cytokine producing cell differentiation induced by PP and SPL cells depending on the antigen dosage were preserved in the absence of IL-12. When the function of CD86 was blocked by specific antibody, the induction of Th1-type cytokine producing cells was kept at high levels through every antigen dose, and the difference between PP and SPL cells was abrogated. With regard to Th2 induction, CD86 enhanced the differentiation of Th2-type cytokine producing cells but it was not essential in the case of antigen presentation by SPL cells. These results suggest that antigen-dose dependent changes in Th2 cell induction are regulated by additional factors which cannot induce antigen-dose dependent changes in Th1 cell differentiation by themselves.

摘要

在这项研究中，我们通过不同剂量的抗原展示，证明了白细胞介素 12（IL-12）、CD80 和 CD86 在派尔氏结（PP）和脾脏（SPL）细胞诱导的 T 辅助型 1（Th1）和 Th2 分化中的作用。研究发现，IL-12 对于诱导 Th1 型细胞因子产生细胞至关重要，而 Th2 型细胞因子产生细胞的分化模式不受 IL-12 阻断的影响，与抗原剂量呈依赖性。此外，在缺乏 IL-12 的情况下，PP 和 SPL 细胞诱导的 Th2 型细胞因子产生细胞分化模式的差异仍得以保留。当用特异性抗体阻断 CD86 的功能时，通过每个抗原剂量都能保持 Th1 型细胞因子产生细胞的高诱导水平，同时消除了 PP 和 SPL 细胞之间的差异。关于 Th2 诱导，CD86 增强了 Th2 型细胞因子产生细胞的分化，但对于 SPL 细胞呈递抗原的情况并非必需。这些结果表明，Th2 细胞诱导的抗原剂量依赖性变化是由其他因素调节的，这些因素本身不能诱导 Th1 细胞分化的抗原剂量依赖性变化。