Zhang Hongmin, Chen Shiwei, Deng Xifang, Yang Xuguang, Huang Xi
Laboratory of Ethnopharmacology, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Diabetes Res Clin Pract. 2006 Nov;74(2):194-6. doi: 10.1016/j.diabres.2006.04.003. Epub 2006 May 19.
Danggui-Buxue-Tang (DBT) is a famous traditional Chinese formula. We examined the anti-inflammatory effect of it in diabetic atherosclerosis rats. DBT (3 or 6g/kg/day for 4 weeks) was orally administrated to the diabetic atherosclerosis rats, which were induced by nitric oxide inhibition (l-NAME in drinking water, 1mg/ml) plus high-fat diet. The concentrations of circulating inflammatory markers C-reactive protein (CRP) and tumour necrosis factor-alpha (TNF-alpha) and serum fructosamine were determined. The results showed that DBT had no direct effect in lowering serum fructosamine level, but can decrease the concentrations of CRP and TNF-alpha, produce a higher survival rate and less body weight loss, and decrease water intake in diabetic atherosclerosis in GK rats.
当归补血汤（DBT）是一种著名的中药方剂。我们研究了其对糖尿病动脉粥样硬化大鼠的抗炎作用。将DBT（3或6克/千克/天，持续4周）口服给予糖尿病动脉粥样硬化大鼠，这些大鼠通过一氧化氮抑制（饮用水中加入1毫克/毫升的L-NAME）加高脂饮食诱导产生。测定了循环炎症标志物C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）的浓度以及血清果糖胺。结果表明，DBT对降低血清果糖胺水平没有直接作用，但可降低CRP和TNF-α的浓度，提高存活率，减少体重减轻，并减少GK大鼠糖尿病动脉粥样硬化中的饮水量。
