Gardin Nilo Esvalter
Phytother Res. 2009 Mar;23(3):407-11. doi: 10.1002/ptr.2643.
European mistletoe (Viscum album) has been used in complementary cancer treatment, but little is known concerning its effects on immunological parameters, although there is evidence that Viscum may stimulate the immune system. In this study, a trial was conducted with cancer patients to determine whether Viscum album extracts could improve the results of immune tests. These were: white blood cell count (leukocytes, neutrophils, lymphocytes), CD4+ and CD8+ T-lymphocytes, intradermal tests of delayed hypersensitivity (candidin, trichophytin, purified protein derivative-PPD), complement C3 and C4, and immunoglobulin A, G and M. Four patients received seven doses of subcutaneous Viscum album 20 mg, twice weekly. Immunological tests were carried out before and after treatment, and an increase in several parameters of humoral and cellular immunity were shown. Apart from reactions around the injection sites, treatment was well tolerated and all patients benefited from it. These results suggest that Viscum album can enhance humoral and cellular immune responses in cancer patients, but further studies attesting to the possible clinical impact of these immunological effects are necessary.
欧洲槲寄生（白果槲寄生）已被用于辅助癌症治疗，尽管有证据表明槲寄生可能刺激免疫系统，但其对免疫参数的影响却鲜为人知。在本研究中，对癌症患者进行了一项试验，以确定白果槲寄生提取物是否能改善免疫测试结果。这些测试包括：白细胞计数（白细胞、中性粒细胞、淋巴细胞）、CD4 + 和CD8 + T淋巴细胞、迟发型超敏反应的皮内试验（念珠菌素、癣菌素、纯化蛋白衍生物-PPD）、补体C3和C4以及免疫球蛋白A、G和M。四名患者每周皮下注射七剂20毫克白果槲寄生，每周两次。在治疗前后进行了免疫测试，结果显示体液免疫和细胞免疫的几个参数有所增加。除注射部位周围的反应外，治疗耐受性良好，所有患者均从中受益。这些结果表明，白果槲寄生可以增强癌症患者的体液免疫和细胞免疫反应，但有必要进行进一步研究以证实这些免疫效应可能产生的临床影响。
