Shen Haitao, Han Jianlong, Tie Xiaowei, Xu Wei, Ren Yiping, Ye Chunsheng
Zhejiang Provincial Center for Disease Prevention and Control, 630 Xin Cheng Road, Binjiang District, Hangzhou 310051, China.
Chemosphere. 2009 Jan;74(3):384-8. doi: 10.1016/j.chemosphere.2008.09.094. Epub 2008 Nov 11.
This is the first report on polychlorinated dibenzo-p-dioxin/furan (PCDD/F) and polychlorinated biphenyl (PCB) contamination of human adipose tissue from China. A total of 24 human adipose tissue samples from a general population in Zhejiang Province were analyzed for PCDD/F and PCB by high-resolution gas chromatography-high-resolution mass spectrometry. Total PCDD/F concentrations in human adipose tissue ranged from 33.9 to 504 pg g(-1)lipid (mean 108 pg g(-1)lipid). Corresponding values for dioxin-like PCBs ranged from 4.1 to 125 ng g(-1)lipid (mean 32.8 ng g(-1)lipid). Mean total WHO toxicity equivalent (TEQ) values for PCDD/Fs and PCBs in human adipose tissue were 9.22 and 16.2 pg g(-1)lipid, respectively. OCDD was the dominant PCDD/F congener, and 2,3,4,7,8-PeCDF and 1,2,3,7,8-PeCDD accounted for more than 70% of the WHO PCDD/F TEQ. In all samples, PCB-118, PCB-156 and PCB-105 were the main PCB congeners. PCB-153 concentrations were the highest of all indicator PCBs (mean 52.5 ng g(-1)lipid). The contamination levels and profiles are compared with those reported for European and Asian countries.
这是关于中国人体脂肪组织中多氯二苯并对二噁英/呋喃（PCDD/F）和多氯联苯（PCB）污染情况的首份报告。采用高分辨率气相色谱-高分辨率质谱法，对来自浙江省普通人群的24份人体脂肪组织样本进行了PCDD/F和PCB分析。人体脂肪组织中PCDD/F的总浓度范围为33.9至504皮克/克脂质（平均108皮克/克脂质）。类二噁英多氯联苯的相应值范围为4.1至125纳克/克脂质（平均32.8纳克/克脂质）。人体脂肪组织中PCDD/F和PCB的平均总世卫组织毒性当量（TEQ）值分别为9.22和16.2皮克/克脂质。八氯二苯并对二噁英是主要的PCDD/F同系物，2,3,4,7,8-五氯二苯并呋喃和1,2,3,7,8-五氯二苯并二噁英占世卫组织PCDD/F TEQ的70%以上。在所有样本中，多氯联苯-118、多氯联苯-156和多氯联苯-105是主要的多氯联苯同系物。多氯联苯-153的浓度在所有指示性多氯联苯中最高（平均52.5纳克/克脂质）。将污染水平和分布情况与欧洲和亚洲国家报告的情况进行了比较。
