Williams D Victoria, Barua Bipasha, Andersen Niels H
Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
Org Biomol Chem. 2008 Dec 7;6(23):4287-9. doi: 10.1039/b814314e. Epub 2008 Oct 15.
The folding enantioselectivity for D-Ala versus L-Ala at one glycine site in the Trp-cage is 16 kJ mol(-1); judicious introductions of alanines of the correct chirality raises the melting temperature of this 20-residue fold to 83 degrees C.
色氨酸笼中一个甘氨酸位点上D-丙氨酸与L-丙氨酸的折叠对映选择性为16 kJ·mol⁻¹；明智地引入正确手性的丙氨酸可将这种20个残基折叠体的解链温度提高到83℃。
