Gu Jia-Hui, Gong Ting-Ting, Wu Qi-Jun, Liu Fang-Hua, Wen Zhao-Yan, Gao Chang, Wei Yi-Fan, Yang Zhuo
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Nutr. 2021 Dec 14;8:758178. doi: 10.3389/fnut.2021.758178. eCollection 2021.
As a result of a limited number of studies and inconsistent findings, there remains uncertainty in whether pre-diagnostic dietary supplements intake affects survival after ovarian cancer (OC) diagnosis. The association between pre-diagnostic dietary supplements intake and all-cause OC mortality was examined in the OC follow-up study, which included a hospital-based cohort ( = 703) of Chinese women diagnosed with OC between 2015 and 2020. Pre-diagnostic dietary supplements information was collected using self-administered questionnaires. Deaths were ascertained up to March 31, 2021, death registry linkage. Cox proportional hazards were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the aforementioned association. A total of 130 women died during the median follow-up of 37.2 months (interquartile: 24.7-50.2 months). We found no evidence that any pre-diagnostic dietary supplements intake compared with never is associated with OC survival (HR = 0.75, 95%CI: 0.47-1.18). Furthermore, our study suggested no association for ever supplements intakes of vitamin A (HR = 0.48, 95%CI: 0.07-3.46), vitamin C (HR = 0.64, 95%CI: 0.27-1.54), vitamin D (HR = 1.19, 95%CI: 0.28-5.03), vitamin E (HR = 0.47, 95%CI: 0.06-3.87), multivitamin (HR = 0.49, 95%CI: 0.14-1.67), calcium (HR = 0.96, 95%CI: 0.53-1.72), and fish oil/DHA (HR = 0.31, 95%CI: 0.04-2.37) with OC survival. Interestingly, we only found a detrimental effect of vitamin B supplementation intake (HR = 3.78, 95%CI: 1.33-0.69) on OC survival. We found no evidence that any pre-diagnostic dietary supplements intake is associated with OC survival. Considering lower exposure of dietary supplements before OC diagnosis in the present study, further studies are warranted to confirm these findings.
由于研究数量有限且结果不一致，卵巢癌（OC）诊断前摄入膳食补充剂是否会影响OC诊断后的生存率仍存在不确定性。在OC随访研究中，对诊断前膳食补充剂摄入与全因OC死亡率之间的关联进行了研究，该研究纳入了一个基于医院的队列（n = 703），这些中国女性在2015年至2020年期间被诊断为OC。使用自填问卷收集诊断前膳食补充剂信息。通过死亡登记链接确定截至2021年3月31日的死亡情况。使用Cox比例风险模型估计上述关联的风险比（HR）和95%置信区间（CI）。在37.2个月的中位随访期（四分位间距：24.7 - 50.2个月）内，共有130名女性死亡。我们没有发现证据表明与从未摄入相比，任何诊断前膳食补充剂摄入与OC生存率相关（HR = 0.75，95%CI：0.47 - 1.18）。此外，我们的研究表明，维生素A（HR = 0.48，95%CI：0.07 - 3.46）、维生素C（HR = 0.64，95%CI：0.27 - 1.54）、维生素D（HR = 1.19，95%CI：0.28 - 5.03）、维生素E（HR = 0.47，95%CI：0.06 - 3.87）、多种维生素（HR = 0.49，95%CI：0.14 - 1.67）、钙（HR = 0.96，95%CI：0.53 - 1.72）以及鱼油/二十二碳六烯酸（HR = 0.31，95%CI：0.04 - 2.37）的既往补充摄入与OC生存率之间均无关联。有趣的是，我们仅发现补充维生素B摄入（HR = 3.7 / 8，95%CI：1.33 - 0.69）对OC生存率有不利影响。我们没有发现证据表明任何诊断前膳食补充剂摄入与OC生存率相关。考虑到本研究中OC诊断前膳食补充剂的暴露较低，有必要进一步研究以证实这些发现。
