Yang Min Hye, Yoon Kee Dong, Chin Young-Won, Park Ju Hyun, Kim Seung Hyun, Kim Young Choong, Kim Jinwoong
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Republic of Korea.
J Ethnopharmacol. 2009 Jan 12;121(1):130-4. doi: 10.1016/j.jep.2008.10.010. Epub 2008 Oct 22.
Plants belong to the genus Dioscorea have long been used as edible tuber crops in many tropical and subtropical areas and as a traditional herbal medicine in oriental countries including China, Japan and Korea.
In this study, in vivo and in vitro tests were carried out to evaluate the cognitive enhancing effects of CHCl(3)-soluble extract from Dioscorea opposita against scopolamine-induced amnesic mice and glutamate- and H(2)O(2)-treated cortical neurons of rats.
MATERIALS, METHODS AND RESULTS: Acute treatment (200 mg/kg body weight, p.o.) and 10 days' daily administration (50 mg/kg body weight, p.o.) of CHCl(3)-soluble extract showed significant spatial learning and memory improvement on mice. Furthermore, the neuroprotective effects on glutamate- and H(2)O(2)-induced neurotoxicity in primary cultured cortical neurons of rats were assessed. Pretreatment with the extract was found to impart significant protection against neurotoxicity.
These in vivo and in vitro results suggest that the Dioscorea opposita has neuroprotective effects on memory impairment related neurodegenerative diseases.
薯蓣属植物长期以来在许多热带和亚热带地区被用作可食用的块茎作物，并在包括中国、日本和韩国在内的东方国家作为传统草药使用。
在本研究中，进行了体内和体外试验，以评估山药三氯甲烷可溶性提取物对东莨菪碱诱导的记忆缺失小鼠以及谷氨酸和过氧化氢处理的大鼠皮质神经元的认知增强作用。
材料、方法和结果：三氯甲烷可溶性提取物的急性处理（200mg/kg体重，口服）和连续10天给药（50mg/kg体重，口服）对小鼠的空间学习和记忆有显著改善。此外，还评估了其对谷氨酸和过氧化氢诱导的大鼠原代培养皮质神经元神经毒性的神经保护作用。发现提取物预处理对神经毒性有显著保护作用。
这些体内和体外结果表明，山药对与记忆障碍相关的神经退行性疾病具有神经保护作用。
