肿瘤病毒的奇闻：伯基特淋巴瘤50年

The curious case of the tumour virus: 50 years of Burkitt's lymphoma.

作者信息

Thorley-Lawson David A, Allday Martin J

机构信息

Department of Pathology, Jaharis Building, Tufts University School of Medicine, 150 Harrison Avenue, Boston, Massachusetts 02111, USA.

出版信息

Nat Rev Microbiol. 2008 Dec;6(12):913-24. doi: 10.1038/nrmicro2015.

DOI:10.1038/nrmicro2015

PMID:19008891

Abstract

Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein-Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and molecular levels, the complex and interesting interaction of EBV with B cells that creates a predisposition for the development of BL. Here, we discuss the intertwined histories of EBV and BL and their relationship to the cofactors in BL pathogenesis: malaria and the MYC translocation.

摘要

伯基特淋巴瘤（BL）于50年前首次被描述，随后不久在BL肿瘤中发现了第一种人类肿瘤病毒——爱泼斯坦-巴尔病毒（EBV）。从那时起，EBV在BL发生发展中的作用变得越来越神秘。直到最近，我们才终于开始在细胞和分子水平上理解EBV与B细胞之间复杂而有趣的相互作用，这种相互作用为BL的发生创造了易感性。在这里，我们将讨论EBV和BL交织的历史，以及它们与BL发病机制中的辅助因素：疟疾和MYC易位之间的关系。