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[使用HemoCue方法在全科医疗中测定血红蛋白浓度:有用但并非完全可靠]

[Determining the haemoglobin concentration in general practice using the HemoCue method: useful but not completely reliable].

作者信息

Eekhof J A H, Groeneveld Y

机构信息

Leids Universitair Medisch Centrum, afd. Public Health en Eerstelijnsgeneeskunde, Postbus 9600, 2300 RC Leiden.

出版信息

Ned Tijdschr Geneeskd. 2008 Oct 18;152(42):2294-7.

Abstract

OBJECTIVE

To determine whether the HemoCue haemoglobin value measured in fingertip skin puncture blood corresponds to the reference value measured in venous blood.

DESIGN

Prospective.

METHOD

In two health centres, patients' blood was first drawn from a fingertip skin puncture and the haemoglobin was measured with the HemoCue method (HemoCue B-Haemoglobin AB photometer, Angelholm, Sweden). The same patients were sent to the regional laboratory for laboratory haemoglobin determination. Agreement between the two haemoglobin values was assessed using the method of Bland and Altman.

RESULTS

Both haemoglobin measurements were carried out in 58 patients. The mean HemoCue haemoglobin was 8.0 mmol/l (95% CI: 7.6-8.4) and the mean venous haemoglobin was 8.2 mmol/l (95% CI: 7.9-8.6). Of all values, 2 were above the level of agreement of 2 SD and 17 values were above the level of 1 SD. The sensitivity of the HemoCue measurement was 81% (95% CI: 62-100) and the specificity 95% (95% CI: 88-100). In the population investigated, with a prevalence of anaemia of 28%, the predictive value of a positive HemoCue result was 87% and of a negative result 93%.

CONCLUSION

According to the test characteristics, the HemoCue is a good device for haemoglobin determination. However, in several cases there is a significant difference between the haemoglobin measured with the HemoCue method and the laboratory haemoglobin value. If a reliable haemoglobin value is needed, a laboratory venous haemoglobin assessment is preferred.

摘要

目的

确定通过指尖皮肤穿刺采血测得的海莫克血红蛋白值是否与静脉血测得的参考值相符。

设计

前瞻性研究。

方法

在两个健康中心,首先从患者指尖进行皮肤穿刺采血,并用海莫克方法(海莫克B型血红蛋白AB光度计,瑞典安吉尔霍姆)测量血红蛋白。这些患者随后被送往区域实验室进行实验室血红蛋白测定。使用布兰德和奥特曼方法评估两种血红蛋白值之间的一致性。

结果

对58例患者进行了两种血红蛋白测量。海莫克血红蛋白的平均值为8.0毫摩尔/升(95%置信区间:7.6 - 8.4),静脉血红蛋白的平均值为8.2毫摩尔/升(95%置信区间:7.9 - 8.6)。在所有测量值中,2个高于2标准差的一致性水平,17个高于1标准差的水平。海莫克测量的敏感性为81%(95%置信区间:62 - 100),特异性为95%(95%置信区间:88 - 10)。在所调查的人群中,贫血患病率为28%,海莫克检测结果为阳性的预测值为87%,阴性结果的预测值为93%。

结论

根据检测特性,海莫克是一种用于测定血红蛋白的良好设备。然而,在一些情况下,用海莫克方法测得的血红蛋白与实验室血红蛋白值之间存在显著差异。如果需要可靠的血红蛋白值,首选实验室静脉血红蛋白评估。

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