HIV 阳性儿童的肾脏疾病
Kidney disease in HIV-positive children.
作者信息
McCulloch Mignon I, Ray Patricio E
机构信息
Red Cross Children's Hospital, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
出版信息
Semin Nephrol. 2008 Nov;28(6):585-94. doi: 10.1016/j.semnephrol.2008.09.001.
Abstract
Before the era of highly active antiretroviral therapy, more than 40% of human immunodeficiency virus (HIV)-infected children experienced renal complications. In sub-Saharan Africa, approximately 2.1 million children are infected with HIV-1. In the absence of antiretroviral therapy, young African children frequently died of AIDS-related complications before renal diseases could be manifested or diagnosed. As antiretroviral therapy has become more available, and their survival has increased, our experience in treating kidney disease in HIV-infected children has improved. This article discusses relevant clinical and pathologic findings related to kidney disease in HIV-infected children.
摘要
在高效抗逆转录病毒治疗时代之前，超过40%的人类免疫缺陷病毒（HIV）感染儿童出现肾脏并发症。在撒哈拉以南非洲地区，约有210万儿童感染了HIV-1。在没有抗逆转录病毒治疗的情况下，非洲幼儿常在肾脏疾病表现出来或被诊断出来之前就死于艾滋病相关并发症。随着抗逆转录病毒治疗的可及性提高，他们的存活率有所增加，我们在治疗HIV感染儿童肾脏疾病方面的经验也有所改善。本文讨论了与HIV感染儿童肾脏疾病相关的临床和病理发现。
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