Adzhigitov F I, Kosichenko L P, Popandopulo P G, Gubeladze D A, Dzhemilev Z A
Tsitol Genet. 1984 May-Jun;18(3):173-6.
A mutagenic effect of aflatoxin B1 (AFB1) was studied in somatic cells of primates. It is shown that AFB1 elevates the chromosome aberration frequency in bone marrow cells of two monkey species: Macaca mulatta and Papio hamadryas. Genome mutations were found in these experimental primates simultaneously with chromosome aberrations. The AFB1-induced chromosome aberrations were revealed at least during two years of the study. The fact of the chromosome aberration frequency increase was established in Macaca babies born from females who received AFB1 in pregnancy.
研究了黄曲霉毒素B1（AFB1）对灵长类动物体细胞的诱变作用。结果表明，AFB1可提高两种猴类（猕猴和阿拉伯狒狒）骨髓细胞中的染色体畸变频率。在这些实验灵长类动物中，与染色体畸变同时发现了基因组突变。在至少两年的研究期间均发现了AFB1诱导的染色体畸变。在孕期接受AFB1的雌性所生的猕猴幼崽中，确定了染色体畸变频率增加这一事实。
