Bárta I, Adámková M, Petr T, Bártová J
Medical Faculty of Hygiene, Charles University, Prague, Czechoslovakia.
Mutat Res. 1990 Jul;244(3):189-95. doi: 10.1016/0165-7992(90)90127-6.
The frequency of chromosomal aberrations in bone marrow cells, after a single i.p. aflatoxin B1 (AFB1) dose, was examined in male Chinese hamsters (Cricetulus griseus). There was a significant increase in aberrant cells within 5 days of administration of a dose of 0.1 micrograms-5 mg AFB1/kg, and on the 36th day. After a single dose of 5 mg AFB1/kg the enhanced frequency of aberrant cells was monitored up to day 104 with no sign of a decrease to control level. The results indicate that the minimum mutagenic effect of an AFB1 dose in this system is 0.1 micrograms/kg. Attention is drawn to the long-term presence of chromosomal aberrations even after a single i.p. exposure to AFB1.
在雄性中国仓鼠（黑线仓鼠）中，检测了腹腔注射单次黄曲霉毒素B1（AFB1）后骨髓细胞中的染色体畸变频率。给予0.1微克至5毫克AFB1/千克剂量后5天内以及第36天，异常细胞显著增加。单次给予5毫克AFB1/千克剂量后，异常细胞频率增加情况一直监测到第104天，未见降至对照水平的迹象。结果表明，该系统中AFB1剂量的最小诱变效应为0.1微克/千克。需注意，即使单次腹腔注射AFB1后，染色体畸变也会长期存在。
