Mathieux R, Marotte H, Battistini L, Sarrazin A, Berthier M, Miossec P
Clinical Immunology Unit, Department of Immunology, Hôpital Edouard Herriot, Lyon, France.
Ann Rheum Dis. 2009 Mar;68(3):400-3. doi: 10.1136/ard.2008.094532. Epub 2008 Nov 17.
The goal of occupational therapy (OT) is to facilitate adjustments to lifestyle and to prevent function loss. This study evaluated the effects of an early OT programme in early rheumatoid arthritis (RA).
We conducted a randomised, blind, controlled trial enrolling 60 patients with early RA, divided into 2 groups. At baseline, group 1 received the full information programme and group 2 received no information. In an extension phase, patients in group 2 received the full information programme at 3 months and were assessed at 6 months. The main outcomes were grip strength of hands (as objective assessment) and Health Assessment Questionnaire (HAQ) score (as subjective assessment).
At 3 months, grip strength of the dominant and non-dominant hands increased more in group 1 than in group 2 (p = 0.021 and 0.047 respectively). HAQ score decreased more in group 1 than in group 2 (p<0.001). In the extension phase, changes in grip strength and HAQ score in group 2 were similar to those seen in group 1 between baseline and 3 months.
This study comparing two schedules of OT programme showed that an early extended information programme improved hand function in patients with early RA.
职业治疗（OT）的目标是促进生活方式的调整并预防功能丧失。本研究评估了早期OT方案对早期类风湿关节炎（RA）的影响。
我们进行了一项随机、盲法、对照试验，纳入60例早期RA患者，分为两组。基线时，第1组接受完整信息方案，第2组未接受任何信息。在延长期，第2组患者在3个月时接受完整信息方案，并在6个月时进行评估。主要结局指标为手部握力（作为客观评估）和健康评估问卷（HAQ）评分（作为主观评估）。
3个月时，第1组优势手和非优势手的握力增加幅度均大于第2组（分别为p = 0.021和0.047）。第1组的HAQ评分下降幅度大于第2组（p<0.001）。在延长期，第2组握力和HAQ评分的变化与第1组在基线至3个月时的变化相似。
本研究比较了两种OT方案时间表，结果表明早期延长信息方案可改善早期RA患者的手部功能。
