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利妥昔单抗成功治疗特发性眼眶炎性疾病。

Idiopathic orbital inflammatory disease successfully treated with rituximab.

作者信息

Schafranski Marcelo Derbli

机构信息

Department of Internal Medicine and Rheumatology, Bom Jesus Hospital, Ponta Grossa, PR, Brazil.

出版信息

Clin Rheumatol. 2009 Feb;28(2):225-6. doi: 10.1007/s10067-008-1040-8. Epub 2008 Nov 15.

DOI:10.1007/s10067-008-1040-8
PMID:19015801
Abstract

We report a case of a 66-year-old Caucasian female with a diagnosis of idiopathic orbital inflammatory disease (OID) refractory to azathioprine therapy. The coexistence of diabetes mellitus represented a relative contraindication to chronic prednisone use. After two infusions of rituximab, a chimeric anti-CD20+ antibody, ophthalmic signs and symptoms remarkably improved. To our knowledge, this is the first case of idiopathic OID successfully treated with rituximab.

摘要

我们报告了一例66岁的白种女性患者，诊断为特发性眼眶炎性疾病（OID），对硫唑嘌呤治疗无效。糖尿病的并存是长期使用泼尼松的相对禁忌证。在输注两次利妥昔单抗（一种嵌合抗CD20 +抗体）后，眼部体征和症状明显改善。据我们所知，这是首例用利妥昔单抗成功治疗的特发性OID病例。

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Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007.《2007年关于治疗风湿性疾病生物制剂的更新共识声明》
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Orbital inflammatory disease.眼眶炎性疾病
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Idiopathic Orbital Inflammation Treated With Rituximab Monotherapy.利妥昔单抗单药治疗特发性眼眶炎症
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Tumefactive fibroinflammatory lesion successfully treated with Rituximab.利妥昔单抗成功治疗肿块性纤维炎性病变。
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Idiopathic Orbital Inflammation: Review of Literature and New Advances.特发性眼眶炎症：文献综述与新进展
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Intraorbital injection of Rituximab in idiopathic orbital inflammatory syndrome: case reports.利妥昔单抗眶内注射治疗特发性眼眶炎性综合征：病例报告
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