Tuvblad Catherine, Zheng Mo, Raine Adrian, Baker Laura A
Department of Psychology, University of Southern California, 3620 S. McClintock Ave., Los Angeles, CA 90089-1061, USA.
J Abnorm Child Psychol. 2009 Feb;37(2):153-67. doi: 10.1007/s10802-008-9278-9.
Previous studies examining the covariation among Attention Deficit Hyperactivity Disorder (ADHD), Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) have yielded inconsistent results. Some studies have concluded that the covariation among these symptoms is due to common genetic influences, whereas others have found a common environmental overlap. The present study investigated the genetic and environmental correlations among these three childhood disorders, based on a sample of 1,219 twins, age 9-10 years. A latent externalizing behavior factor was found to explain the covariance among ADHD, ODD and CD symptoms. Genetic influences explained more than half of the variance in this externalizing factor in both boys and girls. There were also unique genetic and environmental influences in each set of symptoms, suggesting some etiological independence of the three disorders. Our findings have implications for molecular genetic studies trying to identify susceptibility genes for these disorders.
以往研究注意力缺陷多动障碍（ADHD）、对立违抗障碍（ODD）和品行障碍（CD）之间的共变关系，结果并不一致。一些研究得出结论，这些症状之间的共变是由于共同的遗传影响，而另一些研究则发现存在共同的环境重叠。本研究基于1219名9至10岁双胞胎样本，调查了这三种儿童期障碍之间的遗传和环境相关性。发现一个潜在的外化行为因素可以解释ADHD、ODD和CD症状之间的协方差。遗传影响在男孩和女孩中均解释了该外化因素一半以上的变异。每组症状中也存在独特的遗传和环境影响，这表明这三种障碍在病因上存在一定独立性。我们的研究结果对试图识别这些障碍易感基因的分子遗传学研究具有启示意义。
